Jahromi Abdolreza Sotoodeh, Zareian Parvin, Madani Abdolhossein
Department of Immunology, Jahrom University of Medical Sciences, Jahrom, Iran.
Biomark Insights. 2011 Jan 12;6:1-6. doi: 10.4137/BMI.S6150.
The purpose of this study was to evaluate the role of Tumor Necrosis Factor-α (TNF-α) in insulin resistance (IR) during normal pregnancy.
This cross sectional study was carried out on 86 healthy pregnant women including 26, 23 and 37 individuals in the 1st, 2nd and 3rd trimesters, respectively, and in 21 healthy non pregnant women. Serum TNF-α concentration was measured by Enzyme Linked Immunosorbent Assay (ELISA) method.
There were significant differences between serum TNF-α and IL-6 levels in pregnant women as compared with maternal healthy controls. There was significant correlation between gestational age and Body Mass Index (BMI) (r = 0.28, P = 0.01). There was no significant correlation between gestational age and insulin resistance (IR). We also did not find correlations between IR and TNF-α and IR and IL-6 in pregnant women.
In conclusion, our findings suggest that TNF-α and IL-6 are not greatly contributed to pregnancy induced insulin resistance in normal pregnancy.
本研究的目的是评估肿瘤坏死因子-α（TNF-α）在正常妊娠期间胰岛素抵抗（IR）中的作用。
本横断面研究对86名健康孕妇进行，其中分别有26名、23名和37名处于妊娠第一、第二和第三孕期，以及21名健康非孕妇。采用酶联免疫吸附测定（ELISA）法测定血清TNF-α浓度。
与健康孕妇对照组相比，孕妇血清TNF-α和IL-6水平存在显著差异。孕周与体重指数（BMI）之间存在显著相关性（r = 0.28，P = 0.01）。孕周与胰岛素抵抗（IR）之间无显著相关性。我们也未发现孕妇IR与TNF-α以及IR与IL-6之间存在相关性。
总之，我们的研究结果表明，TNF-α和IL-6对正常妊娠中妊娠诱导的胰岛素抵抗贡献不大。
