Department of Chemistry, Federal Urdu University for Arts, Science and Technology,Gulshan-e-Iqbal Campus, Karachi 75300, Pakistan.
Nat Prod Res. 2011 Apr;25(7):750-3. doi: 10.1080/14786419.2010.513684.
Seven secondary metabolites, p-hydroxybenzoic acid (1), 3,4-dihydroxybenzoic acid (2), ferulic acid (3), 2,6-dimethoxy-4-hydroxy acetophenone (4), lupeol (5), 2'-O-ethylmurrangatin (6) and hibiscetin heptamethyl ether (7) were the natural products isolated from various medicinal plants. Their structures were identified by spectral comparison with previously reported data. The compounds 1-7 were screened for their tyrosinase-inhibitory activity. The compound p-hydroxybenzoic acid (1) was found to have potent activity against tyrosinase enzyme, whereas lupeol (5) showed significant activity.
从各种药用植物中分离得到的 7 种次生代谢产物，分别为对羟基苯甲酸（1）、3,4-二羟基苯甲酸（2）、阿魏酸（3）、2,6-二甲氧基-4-羟基苯乙酮（4）、羽扇豆醇（5）、2'-O-乙基芒果苷（6）和 hibiscetin 十七甲醚（7）。通过与先前报道的数据进行光谱比较，鉴定了它们的结构。对这些化合物 1-7 进行了酪氨酸酶抑制活性筛选。结果发现，对羟基苯甲酸（1）对酪氨酸酶具有很强的抑制活性，而羽扇豆醇（5）则表现出显著的活性。
