Höing A, Remy M, Dirisamer M, Priglinger S, Schönfeld C L, Kampik A, Haritoglou C
Augenklinik der LMU, Campus Innenstadt, Mathildenstrasse 8, Munich.
Klin Monbl Augenheilkd. 2011 Aug;228(8):724-8. doi: 10.1055/s-0031-1273351. Epub 2011 Apr 8.
The aim of this study was to evaluate the functional outcome of Brilliant Blue G (BBG) and the staining properties in macular surgery.
BBG was applied during vitrectomy for macular holes (n = 21) or epiretinal membranes (n = 18) in a prospective, non-comparative consecutive series of patients (Brilliant Peel®; Fluoron® GmbH, Neu-Ulm, Germany). Before and after surgery all patients underwent a complete clinical examination including measurement of best corrected visual acuity and intraocular pressure, perimetry, fundus photography and optical coherence tomography.
Vitrectomy was performed in combination with a cataract operation in 14 patients. All macular holes were closed successfully. Visual acuity was in average 0.16 preoperatively in macular hole cases and increased up to 0.4 after 6 months. Visual acuity of patients with epiretinal membranes changed on average from 0.3 to 0.45 after 6 months. The retina thickness in patients with epiretinal membranes was initially 402.6 µm according to the OCT and 304.7 µm after 6 months postoperatively. No toxic effects attributable to the dye were noted during patient follow-up, especially all perimetry tests were normal.
Brilliant blue provides a sufficient and selective staining of the ILM. No retinal toxicity or adverse effects related to the dye were observed in this study. The long-term safety of this dye will have to be evaluated in larger patient series and a longer follow-up.
本研究旨在评估亮蓝G（BBG）在黄斑手术中的功能结局及染色特性。
在一系列前瞻性、非对照连续患者（Brilliant Peel®；德国新乌尔姆市Fluoron® GmbH公司）中，于玻璃体切割术治疗黄斑裂孔（n = 21）或视网膜前膜（n = 18）时应用BBG。手术前后所有患者均接受全面的临床检查，包括测量最佳矫正视力、眼压、视野检查、眼底照相及光学相干断层扫描。
14例患者在玻璃体切割术的同时进行了白内障手术。所有黄斑裂孔均成功封闭。黄斑裂孔患者术前平均视力为0.16，6个月后提高至0.4。视网膜前膜患者的视力在6个月后平均从0.3提高至0.45。根据光学相干断层扫描，视网膜前膜患者的视网膜厚度最初为402.6 µm，术后6个月为304.7 µm。在患者随访期间未发现染料所致的毒性作用，尤其是所有视野检查均正常。
亮蓝对内界膜有充分且选择性的染色作用。本研究中未观察到与染料相关的视网膜毒性或不良反应。该染料的长期安全性有待在更大规模的患者系列及更长时间的随访中进行评估。
