Digestive Endoscopy Unit, Catholic University of Rome, Largo A. Gemelli, 8, 00168 Rome, Italy.
Surg Endosc. 2011 Sep;25(9):3050-6. doi: 10.1007/s00464-011-1669-2. Epub 2011 Apr 13.
The last decade has seen significant advances in the evaluation of the small bowel. Several endoscopic techniques have been developed in recent years: capsule endoscopy (CE), double-balloon enteroscopy (DBE), and, more recently, the single-balloon enteroscopy (SBE). The aim of this study was to evaluate diagnostic and therapeutic impact, safety, and feasibility of the SBE procedure after a 3-year experience.
A total of 73 SBE procedures were performed from July 2006 to July 2009. The starting insertion route (oral or anal) of SBE was chosen according to the estimated location of the suspected lesions based on the clinical presentation and, in 48 patients, on the findings of CE. A total of 70 patients with obscure gastrointestinal bleeding (31), suspected malabsorption syndrome (12), polyposis syndromes (11), suspected Crohn's disease (9), and suspected gastrointestinal tumors (7) were recruited.
The SBE was not carried out in four patients because of technical problems. Multiple angiodysplasias were found and treated in 9 patients; Peutz-Jeghers syndrome, familial adenomatous polyposis (FAP), and multiple polypectomies were carried out in 8 patients; endoscopic tattoos were performed in 2 patients due to the large diameter of the polyps; and multiple biopsies was performed in only one patient. SBE diagnosed Crohn's disease in four patients, malabsorption syndromes in two, lymphangiectasia in two, eosinophilic enteritis in one, melanoma in one, and nonspecific inflammation in eight. A total of seven small-bowel tumors were diagnosed (all were tattooed). In 23/70 patients the exam was negative. No major complications occurred.
Single-balloon enteroscopy seems to be safe, useful, and highly effective in the diagnosis and therapy of several small-bowel diseases.
过去十年中,小肠评估技术取得了显著进步。近年来已经开发出几种内镜技术:胶囊内镜(CE)、双气囊小肠镜(DBE),以及最近的单气囊小肠镜(SBE)。本研究旨在评估 3 年经验后 SBE 操作的诊断和治疗效果、安全性和可行性。
2006 年 7 月至 2009 年 7 月共进行了 73 例 SBE 操作。SBE 的起始插入途径(口腔或肛门)根据基于临床表现和 48 例患者的 CE 结果的疑似病变的估计位置来选择。共招募了 70 例有不明原因胃肠道出血(31 例)、疑似吸收不良综合征(12 例)、息肉病综合征(11 例)、疑似克罗恩病(9 例)和疑似胃肠道肿瘤(7 例)的患者。
由于技术问题,有 4 例患者未进行 SBE。9 例患者发现并治疗了多处血管扩张症;8 例患者进行了 Peutz-Jeghers 综合征、家族性腺瘤性息肉病(FAP)和多发性息肉切除术;2 例患者因息肉直径较大而行内镜纹身;仅 1 例患者进行了多次活检。SBE 诊断出 4 例克罗恩病、2 例吸收不良综合征、2 例淋巴管扩张症、1 例嗜酸性肠炎、1 例黑色素瘤和 8 例非特异性炎症。共诊断出 7 例小肠肿瘤(均进行了纹身)。70 例患者中有 23 例检查结果为阴性。无重大并发症发生。
单气囊小肠镜在诊断和治疗多种小肠疾病方面是安全、有用且高效的。