Oono Shinichirou, Kurimoto Takuji, Kashimoto Ryosuke, Tagami Yuichi, Okamoto Norio, Mimura Osamu
Department of Ophthalmology, Hyogo College of Medicine, Hyogo, Japan.
Clin Ophthalmol. 2011;5:397-402. doi: 10.2147/OPTH.S17751. Epub 2011 Mar 23.
To investigate the effects of transcorneal electrical stimulation (TES) on eyes that have a branch retinal artery occlusion (BRAO).
We studied two eyes having a BRAO, with an interval between the onset of symptoms and the beginning of treatment of >16 weeks (longstanding cases), and in three eyes with an interval of <16 weeks (fresh cases). The visual functions of the eyes were assessed by the best-corrected visual acuity (BCVA), multifocal electroretinograms (mfERGs), and automated static perimetry with the Humphrey field analyzer (HFA). The mfERGs were recorded before and 1 month after the TES, and perimetry with the HFA was done before and at 1 and 3 months after the TES. The amplitudes and implicit times of the N1, P1, and N2 components of the mfERGs were analyzed.
TES did not alter the BCVA significantly in all eyes, but it led to a significant increase in the amplitude of the N2 wave of the mfERGs (P < 0.01). The amplitude of the N1-P1 was also increased but not significantly. The implicit times of N1 (P < 0.01) and P1 (P < 0.05) were significantly shorter than that before the TES. The mean deviation of the HFA was increased after the TES but only in the longstanding cases.
Our results indicate that TES improves the visual function in eyes with BRAO, mainly in longstanding cases.
研究经角膜电刺激（TES）对视网膜分支动脉阻塞（BRAO）眼的影响。
我们研究了2例BRAO患者的眼睛，症状发作至治疗开始的间隔时间>16周（长期病例），以及3例间隔时间<16周的眼睛（新鲜病例）。通过最佳矫正视力（BCVA）、多焦视网膜电图（mfERG）以及使用 Humphrey 视野分析仪（HFA）进行自动静态视野检查来评估眼睛的视觉功能。在TES前和TES后1个月记录mfERG，并在TES前、TES后1个月和3个月进行HFA视野检查。分析mfERG的N1、P1和N2成分的振幅和隐含时间。
TES在所有眼中均未显著改变BCVA，但导致mfERG的N2波振幅显著增加（P<0.01）。N1 - P1的振幅也有所增加，但不显著。N1（P<0.01）和P1（P<0.05）的隐含时间明显短于TES前。TES后HFA的平均偏差增加，但仅在长期病例中出现。
我们的结果表明，TES可改善BRAO眼的视觉功能，主要是在长期病例中。
