Department of Neuropsychiatry, The Barberry National Centre for Mental Health, Birmingham, United Kingdom.
Mov Disord. 2011 Mar;26(4):735-8. doi: 10.1002/mds.23434. Epub 2010 Nov 10.
Tourette syndrome (TS) is a neurodevelopmental disorder involving tics, which is frequently accompanied by comorbid obsessive compulsive (OCD) or attention deficit hyperactivity disorder (ADHD). Individuals with TS often report poor quality of life (QoL) in comparison with the general population. This study investigated the clinical correlates of QoL in young people with TS using a self-report multidimensional QoL measure, and a range of clinical scales used to assess tic severity and the symptoms of anxiety, depression, OCD, ADHD and other emotional and behavioral symptoms. Symptoms of depression, OCD, and ADHD appeared to have a widespread negative impact on QoL, but poorer QoL was not associated with increased tic severity. Greater emotional and behavioral difficulties, including symptoms of OCD, were among the best predictors of poor QoL in young people with TS.
妥瑞氏症候群（TS）是一种神经发育障碍，涉及抽搐，常伴有合并的强迫症（OCD）或注意力缺陷多动障碍（ADHD）。与一般人群相比，妥瑞氏症候群患者通常报告生活质量（QoL）较差。本研究使用自我报告的多维 QoL 量表以及一系列用于评估抽搐严重程度以及焦虑、抑郁、强迫症、ADHD 和其他情绪和行为症状的临床量表，研究了年轻人妥瑞氏症候群的 QoL 临床相关性。抑郁、强迫症和 ADHD 的症状似乎对 QoL 产生了广泛的负面影响，但 QoL 较差与抽搐严重程度增加无关。包括强迫症症状在内的更多情绪和行为困难是年轻人妥瑞氏症候群 QoL 较差的最佳预测指标之一。
