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Arterioscler Thromb Vasc Biol. 2011 May;31(5):969-79. doi: 10.1161/ATVBAHA.110.207415.
Atherosclerosis is a chronic inflammatory disease of the arterial wall driven by innate and adaptive immune responses. Inflammation controls the development and the destabilization of arterial plaque. Cells involved in the atherosclerotic process secrete and are activated by soluble factors, known as cytokines. Important recent advances in the comprehension of the mechanisms of atherosclerosis have provided evidence for a dual role of cytokines: proinflammatory and T helper-1-related cytokines promote the development and progression of the disease, whereas antiinflammatory and regulatory T cell-related cytokines exert clear antiatherogenic activities. This review focuses on recent advances regarding the role of cytokines, with the exception of chemokines, in the development, progression, and complications of atherosclerosis.
动脉粥样硬化是一种由先天和适应性免疫反应驱动的动脉壁慢性炎症性疾病。炎症控制着动脉斑块的发展和不稳定。参与动脉粥样硬化过程的细胞分泌并被称为细胞因子的可溶性因子激活。对动脉粥样硬化机制的理解的重要最新进展为细胞因子的双重作用提供了证据：促炎和辅助性 T 细胞 1 相关细胞因子促进疾病的发展和进展，而抗炎和调节性 T 细胞相关细胞因子则发挥明确的抗动脉粥样硬化作用。本综述重点介绍了细胞因子（除趋化因子外）在动脉粥样硬化的发展、进展和并发症中的作用的最新进展。
