系统性红斑狼疮患者角膜的生物力学特性。
The biomechanical properties of the cornea in patients with systemic lupus erythematosus.
机构信息
Beyoglu Eye Research and Training Hospital, Istanbul, Turkey.
出版信息
Eye (Lond). 2011 Aug;25(8):1005-9. doi: 10.1038/eye.2011.99. Epub 2011 May 6.
UNLABELLED
PUPOSE: The purpose of this study was to compare the biomechanical properties of the cornea and intraocular pressure (IOP) between patients with systemic lupus erythematosis (SLE) and age-matched controls.
PATIENTS AND METHODS
In this prospective study, 30 healthy individuals (control group) and 30 patients with SLE (study group) underwent Reichert ocular response analyzer (ORA) measurements. In the right eye of each participant, the corneal hysteresis (CH), corneal resistance factor (CRF), and Goldman-related IOP (IOPg) were recorded using the ORA.
RESULTS
Mean CH, CRF, IOPg were significantly different between groups. Mean CH was 10.2 ± 0.6 mm Hg in the study group and 11.3 ± 1.3 in the control group (P=0.02); mean CRF was 9.7 ± 1.1 mm Hg and 11.9 ± 1.5 mm Hg, respectively (P=0.001). Mean IOP(g) was 13.9 ± 2.9 mm Hg in the study group and 16.9 ± 2.6 mm Hg in the control group (P=0.001).
CONCLUSION
The biomechanical properties of the cornea are altered in patients with SLE compared with normal controls. These findings should be taken into account when measuring IOP values in patients with SLE as IOP readings may be underestimated in SLE eyes.
目的
本研究旨在比较系统性红斑狼疮（SLE）患者与年龄匹配对照者的角膜和眼内压（IOP）的生物力学特性。
方法
在这项前瞻性研究中，30 名健康个体（对照组）和 30 名 SLE 患者（研究组）接受了 Reichert 眼反应分析仪（ORA）测量。在每位参与者的右眼，使用 ORA 记录角膜滞后（CH）、角膜阻力因子（CRF）和 Goldman 相关IOP（IOPg）。
结果
两组间平均 CH、CRF、IOPg 存在显著差异。研究组平均 CH 为 10.2 ± 0.6mmHg，对照组为 11.3 ± 1.3mmHg（P=0.02）；平均 CRF 分别为 9.7 ± 1.1mmHg 和 11.9 ± 1.5mmHg（P=0.001）。研究组平均 IOP（g）为 13.9 ± 2.9mmHg，对照组为 16.9 ± 2.6mmHg（P=0.001）。
结论
与正常对照组相比，SLE 患者的角膜生物力学特性发生改变。在测量 SLE 患者的 IOP 值时，应考虑这些发现，因为 SLE 眼中的 IOP 读数可能被低估。
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