硒化铜纳米晶体用于光热治疗。
Copper selenide nanocrystals for photothermal therapy.
机构信息
Department of Chemical Engineering, Texas Materials Institute, Center for Nano- and Molecular Science and Technology, Austin, Texas 78712, United States.
出版信息
Nano Lett. 2011 Jun 8;11(6):2560-6. doi: 10.1021/nl201400z. Epub 2011 May 10.
Abstract
Ligand-stabilized copper selenide (Cu(2-x)Se) nanocrystals, approximately 16 nm in diameter, were synthesized by a colloidal hot injection method and coated with amphiphilic polymer. The nanocrystals readily disperse in water and exhibit strong near-infrared (NIR) optical absorption with a high molar extinction coefficient of 7.7 × 10(7) cm(-1) M(-1) at 980 nm. When excited with 800 nm light, the Cu(2-x)Se nanocrystals produce significant photothermal heating with a photothermal transduction efficiency of 22%, comparable to nanorods and nanoshells of gold (Au). In vitro photothermal heating of Cu(2-x)Se nanocrystals in the presence of human colorectal cancer cell (HCT-116) led to cell destruction after 5 min of laser irradiation at 33 W/cm(2), demonstrating the viabilitiy of Cu(2-x)Se nanocrystals for photothermal therapy applications.
摘要
配体稳定的铜硒化物（Cu(2-x)Se）纳米晶体，直径约为 16nm，通过胶体热注射法合成，并包覆两亲聚合物。纳米晶体在水中容易分散，并表现出强的近红外（NIR）光学吸收，在 980nm 处具有 7.7×10(7)cm(-1)M(-1)的高摩尔消光系数。当用 800nm 的光激发时，Cu(2-x)Se 纳米晶体产生显著的光热加热，光热转换效率为 22%，与金（Au）的纳米棒和纳米壳相当。在人结直肠癌细胞（HCT-116）存在的情况下，Cu(2-x)Se 纳米晶体的体外光热加热导致在 33 W/cm(2)的激光照射 5 分钟后细胞破坏，证明了 Cu(2-x)Se 纳米晶体在光热治疗应用中的可行性。
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