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多种巨噬细胞抑制因子对阴道和全身性2型单纯疱疹病毒感染的比较

Comparison of various macrophage-inhibitory agents on vaginal and systemic herpes simplex virus type 2 infections.

作者信息

McGeorge M B, Morahan P S

出版信息

Infect Immun. 1978 Nov;22(2):623-6. doi: 10.1128/iai.22.2.623-626.1978.

Abstract

Pretreatment of mice intraperitoneally with silica, trypan blue, or dextran sulfate to inhibit macrophage function markedly increased the lethality of a systemic intravenous infection with herpes simplex virus type 2, but did not affect the lethality or local virus growth after vaginal infection of mice with herpes simplex virus type 2. Agents which inhibit macrophage function by different mechanisms decreased host resistance to herpes simplex virus type 2, but the effects of macrophage-inhibitory agents may vary according to the route of virus infection.

摘要

用二氧化硅、台盼蓝或硫酸葡聚糖对小鼠进行腹腔预处理以抑制巨噬细胞功能,可显著增加2型单纯疱疹病毒全身静脉感染的致死率,但不影响2型单纯疱疹病毒经阴道感染小鼠后的致死率或局部病毒生长。通过不同机制抑制巨噬细胞功能的药物会降低宿主对2型单纯疱疹病毒的抵抗力,但巨噬细胞抑制药物的效果可能因病毒感染途径而异。

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