精神分裂症患者自然死因的预测因素：社区队列的 10 年随访。
Predictors of death from natural causes in schizophrenia: 10-year follow-up of a community cohort.
机构信息
Hampshire Partnership NHS Foundation Trust, Cannon House, 6 Cannon Street, Shirley, Southampton, SO15 5PQ, UK.
出版信息
Soc Psychiatry Psychiatr Epidemiol. 2012 Jun;47(6):843-7. doi: 10.1007/s00127-011-0392-6. Epub 2011 May 11.
PURPOSE
People with schizophrenia have increased natural mortality. There is much speculation but little evidence about the reasons behind this. This paper describes a study designed to measure the impact of pre-selected clinical, demographic and lifestyle variables on the natural mortality of a cohort with schizophrenia.
METHODS
Ten-year Cox proportional hazards regression analysis of a community cohort of 95 people with schizophrenia.
RESULTS
Death from natural causes was significantly associated with psychosis (HR 2.62, 95% CI 1.13-6.07), age (HR 1.08, 95% CI 1.02-1.13) and cigarette smoking (HR 2.53, 95% CI 1.01-6.34) at outset. There was a trend to association with low dietary unsaturated fat (P = 0.06).
CONCLUSIONS
Active psychosis appears to predict natural mortality in people with schizophrenia. Mental health services should prioritise the effective treatment of psychosis. Further research is needed to clarify other risk factors and evaluate health promotion interventions.
目的
精神分裂症患者的自然死亡率增加。尽管对此有很多猜测，但几乎没有证据表明其背后的原因。本文描述了一项旨在衡量预先选择的临床、人口统计学和生活方式变量对精神分裂症患者队列自然死亡率影响的研究。
方法
对社区队列中的 95 名精神分裂症患者进行为期 10 年的 Cox 比例风险回归分析。
结果
自然原因导致的死亡与精神病（HR 2.62，95%CI 1.13-6.07）、发病时年龄（HR 1.08，95%CI 1.02-1.13）和吸烟（HR 2.53，95%CI 1.01-6.34）显著相关。与低膳食不饱和脂肪呈趋势相关（P=0.06）。
结论
活跃的精神病似乎可以预测精神分裂症患者的自然死亡率。精神卫生服务应优先有效治疗精神病。需要进一步研究以阐明其他危险因素并评估健康促进干预措施。
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