Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Org Lett. 2011 Jun 17;13(12):3016-9. doi: 10.1021/ol2008473. Epub 2011 May 16.
Three new heteroaromatic alkaloids, nakijinamines C-E (1-3), which are a hybrid of the aaptamine-type and bromoindole alkaloids possessing a taurine- or histidine-derived residue, have been isolated from an Okinawan marine sponge Suberites species. The structures of 1-3 were elucidated on the basis of spectroscopic data and chemical conversions. Nakijinamines C (1) and E (3) are the first natural products possessing a 1H-oxazolo[4',5':4,5]benzo[1,2,3-de][1,6]naphthyridine ring system.
从冲绳海洋海绵 Suberites 种中分离得到三种新的杂芳族生物碱，nakijinamines C-E（1-3），它们是 aaptamine 型和溴吲哚生物碱的混合物，具有牛磺酸或组氨酸衍生的残留物。基于光谱数据和化学转化，阐明了 1-3 的结构。nakijinamines C（1）和 E（3）是具有 1H-恶唑[4',5':4,5]苯并[1,2,3-de][1,6]萘啶环系统的第一个天然产物。
