Dermatology Research Centre, The University of Queensland, School of Medicine, Princess Alexandra Hospital, 199 Ipswich Road, Brisbane, Qld 4102, Australia.
Br J Dermatol. 2011 Oct;165(4):735-42. doi: 10.1111/j.1365-2133.2011.10416.x. Epub 2011 Aug 4.
As our understanding of the role of ultraviolet (UV) radiation exposure in causing skin cancer continues to be enhanced, it is important that clinicians and researchers are familiar with the various methods for assessing photodamage to skin. This paper provides a systematic review of the published literature on invasive and noninvasive methods used to quantify lifetime UV exposure ('photoageing'). Clinical examination, histopathology, immunohistochemistry, skin surface topography and ultrasound, in addition to newer technologies such as reflectance confocal microscopy, optical coherence tomography and multiphoton tomography, are reviewed. It is concluded that histopathological solar elastosis alone should not be viewed as a 'gold standard' diagnostic test and that there is no single method available to give accurate quantification of the degenerative changes associated with photodamage. Although additional research into sensitivity and specificity is still needed, skin surface topography currently has the most support in the literature as a valid and reliable noninvasive tool for the assessment of photoageing.
随着我们对紫外线（UV）辐射暴露在导致皮肤癌中的作用的理解不断加深，临床医生和研究人员熟悉评估皮肤光损伤的各种方法非常重要。本文系统回顾了评估终生紫外线暴露（“光老化”）的已发表文献，包括侵入性和非侵入性方法。临床检查、组织病理学、免疫组织化学、皮肤表面形貌和超声，以及反射共聚焦显微镜、光相干断层扫描和多光子断层扫描等新技术，都进行了回顾。结论是，单纯的组织病理学光弹性单独不应被视为“金标准”诊断测试，也没有一种方法可准确量化与光损伤相关的退行性变化。尽管仍需要对敏感性和特异性进行更多研究，但目前皮肤表面形貌在文献中作为评估光老化的有效且可靠的非侵入性工具得到了最多的支持。
