Mental Health Institute, the 2nd Xiangya Hospital, Central South University, Changsha 410011, China.
BMC Psychiatry. 2011 May 15;11:84. doi: 10.1186/1471-244X-11-84.
The 32-item Hypomania Checklist (HCL-32), a questionnaire for screening bipolar disorders, has been utilised in several countries, but it unclear if the Chinese version of the HCL-32 is valid.
Consecutive patients with bipolar disorders (BP, N = 300) and unipolar major depression (UP, N = 156) completed the Chinese version of the HCL-32. The subjects underwent a structured clinical interview for DSM-IV Axis-I disorders (SCID).
The eigenvalues for the first three factors in the HCL-32 were calculated as 5.16 (active/elated), 2.72 (risk-taking) and 2.48 (irritable) using factor analysis. Cronbach's alpha for the HCL-32 was calculated to be 0.88. Positive responses to twenty-eight items were significantly more frequent by patients with BP than those with UP, and the other four items (7th, 21st, 25th and 32nd) showed no such trend. Fourteen was the optimal cut-off for discriminating between BP and UP. The HCL-32 distinguished between BP-II and UP, with 13 being the optimal cut-off. A cut-off of 13 yielded a sensitivity of 0.77 and a specificity of 0.62 between BP and UP.
This study demonstrated that the simplified Chinese version of HCL-32 was valid for patients with mood disorders. The optimal cut-off of 13 for distinguishing between BP-II and UP was valid and could be used to improve the sensitivity of screening BP-II patients when the HCL-32 is used in psychiatric settings in China.
32 项轻躁狂清单（HCL-32）是一种用于筛查双相情感障碍的问卷，已在多个国家使用，但尚不清楚 HCL-32 的中文版本是否有效。
连续入组的双相情感障碍（BP，N=300）和单相重性抑郁（UP，N=156）患者完成了 HCL-32 的中文版。受试者接受了DSM-IV 轴 I 障碍的结构临床访谈（SCID）。
因子分析计算 HCL-32 的前三个因子的特征值分别为 5.16（活跃/兴奋）、2.72（冒险）和 2.48（易怒）。HCL-32 的克朗巴赫 α值计算为 0.88。BP 患者对 28 个项目的阳性反应明显多于 UP 患者，而另外 4 个项目（第 7、21、25 和 32 项）则没有这种趋势。14 是区分 BP 和 UP 的最佳截断值。HCL-32 可区分 BP-II 和 UP，最佳截断值为 13。13 的截断值在 BP 和 UP 之间的灵敏度为 0.77，特异性为 0.62。
本研究表明，简化的 HCL-32 中文版对心境障碍患者有效。13 用于区分 BP-II 和 UP 的最佳截断值有效，可用于提高 HCL-32 在我国精神科环境中筛查 BP-II 患者的灵敏度。
