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Dissemination of blaKPC-2 by the spread of Klebsiella pneumoniae clonal complex 258 clones (ST258, ST11, ST437) and plasmids (IncFII, IncN, IncL/M) among Enterobacteriaceae species in Brazil.blaKPC-2 通过肺炎克雷伯菌克隆群 258 克隆（ST258、ST11、ST437）和质粒（IncFII、IncN、IncL/M）在巴西肠杆菌科物种中的传播。
Antimicrob Agents Chemother. 2011 Jul;55(7):3579-83. doi: 10.1128/AAC.01783-10. Epub 2011 May 16.
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Molecular Analysis of -Harboring Plasmids: Tn Interplasmid Transposition and Tn-Carrying ColRNAI Plasmid Mobilization from Klebsiella pneumoniae to Citrobacter europaeus and Morganella morganii in a Single Patient.携带 - 基因的质粒的分子分析：肺炎克雷伯菌到肠杆菌属和摩氏摩根菌中单例患者体内的Tn 质粒转座和 Tn 携带 ColRNAI 质粒的转移。
mSphere. 2021 Dec 22;6(6):e0085021. doi: 10.1128/mSphere.00850-21. Epub 2021 Nov 3.
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Early OXA-48-Producing Isolates Recovered in a Spanish Hospital Reveal a Complex Introduction Dominated by Sequence Type 11 (ST11) and ST405 Klebsiella pneumoniae Clones.西班牙某医院分离到的早期产 OXA-48 菌株揭示了 11 型（ST11）和 ST405 型肺炎克雷伯菌克隆主导的复杂传播途径。
mSphere. 2020 Apr 8;5(2):e00080-20. doi: 10.1128/mSphere.00080-20.
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Multiclonal dispersal of KPC genes following the emergence of non-ST258 KPC-producing Klebsiella pneumoniae clones in Madrid, Spain.多克隆传播的 KPC 基因后出现的非 ST258 产 KPC 肺炎克雷伯菌克隆在马德里，西班牙。
J Antimicrob Chemother. 2013 Nov;68(11):2487-92. doi: 10.1093/jac/dkt237. Epub 2013 Jun 20.
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Molecular characteristics of KPC-producing Enterobacteriaceae at the early stage of their dissemination in Poland, 2008-2009.2008-2009 年波兰肠杆菌科产 KPC 细菌传播早期的分子特征。
Antimicrob Agents Chemother. 2011 Dec;55(12):5493-9. doi: 10.1128/AAC.05118-11. Epub 2011 Sep 19.
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Genetic Diversity of KPC-Producing Escherichia coli, Klebsiella oxytoca, Serratia marcescens, and Citrobacter freundii Isolates from Argentina.来自阿根廷的产KPC的大肠杆菌、产酸克雷伯菌、粘质沙雷氏菌和弗氏柠檬酸杆菌分离株的遗传多样性
Microb Drug Resist. 2018 Sep;24(7):958-965. doi: 10.1089/mdr.2017.0213. Epub 2017 Dec 13.
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Molecular epidemiology of carbapenem resistant Enterobacteriaceae in Valle d'Aosta region, Italy, shows the emergence of KPC-2 producing Klebsiella pneumoniae clonal complex 101 (ST101 and ST1789).意大利瓦莱达奥斯塔地区耐碳青霉烯类肠杆菌科的分子流行病学研究显示，产 KPC-2 的肺炎克雷伯菌克隆复合体 101（ST101 和 ST1789）的出现。
BMC Microbiol. 2015 Nov 9;15(1):260. doi: 10.1186/s12866-015-0597-z.
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Outbreak of KPC-2-producing Enterobacteriaceae caused by clonal dissemination of Klebsiella pneumoniae ST307 carrying an IncX3-type plasmid harboring a truncated Tn4401a.由携带截短型Tn4401a的IncX3型质粒的肺炎克雷伯菌ST307克隆传播引起的产KPC-2肠杆菌科细菌暴发。
Diagn Microbiol Infect Dis. 2017 Apr;87(4):343-348. doi: 10.1016/j.diagmicrobio.2016.12.012. Epub 2016 Dec 27.
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Pandemic spread of bla among Klebsiella pneumoniae ST11 in China is associated with horizontal transfer mediated by IncFII-like plasmids.在中国，肺炎克雷伯菌 ST11 中 bla 的流行与 IncFII 样质粒介导的水平转移有关。
Int J Antimicrob Agents. 2019 Aug;54(2):117-124. doi: 10.1016/j.ijantimicag.2019.03.014. Epub 2019 Mar 15.
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Dissemination of the blaKPC gene by clonal spread and horizontal gene transfer: comparative study of incidence and molecular mechanisms.blaKPC基因通过克隆传播和水平基因转移的传播：发病率及分子机制的比较研究
J Antimicrob Chemother. 2016 Aug;71(8):2143-6. doi: 10.1093/jac/dkw106. Epub 2016 Apr 12.
引用本文的文献
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Different effects of plasmids harboring between major and minor clones in .携带不同质粒在……中主要克隆体和次要克隆体之间的不同影响。 （原句表述不太完整清晰，翻译可能会稍显生硬，你可检查一下原文是否准确完整）
Microbiol Spectr. 2025 Aug 5;13(8):e0212624. doi: 10.1128/spectrum.02126-24. Epub 2025 Jun 12.
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Clonal dissemination and persistence of Carbapenem-resistant harbouring ST307 in a Tertiary Hospital in the Republic of Korea.韩国一家三级医院中携带ST307的耐碳青霉烯菌的克隆传播与持续存在。
JAC Antimicrob Resist. 2025 May 30;7(3):dlaf090. doi: 10.1093/jacamr/dlaf090. eCollection 2025 Jun.
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Dissemination of IncQ1 Plasmids Harboring NTE-IId in a Brazilian Hospital.巴西一家医院中携带NTE-IId的IncQ1质粒的传播。
Microorganisms. 2025 Jan 16;13(1):180. doi: 10.3390/microorganisms13010180.
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Multiple regional outbreaks caused by global and local VIM-producing Klebsiella pneumoniae clones in Poland, 2006-2019.2006年至2019年期间，波兰因全球和本地产VIM的肺炎克雷伯菌克隆株引发的多起区域性疫情。
Eur J Clin Microbiol Infect Dis. 2025 Mar;44(3):619-628. doi: 10.1007/s10096-024-05016-1. Epub 2024 Dec 21.
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Virulence plasmid with IroBCDN deletion promoted cross-regional transmission of ST11-KL64 carbapenem-resistant hypervirulent Klebsiella pneumoniae in central China.携带 IroBCDN 缺失的毒力质粒促进了中国中部 ST11-KL64 碳青霉烯类耐药超级毒力肺炎克雷伯菌的跨区域传播。
BMC Microbiol. 2024 Oct 10;24(1):400. doi: 10.1186/s12866-024-03564-2.
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First report of a -producing extensively drug resistant ST437 in Italy.首次在意大利报告产生广泛耐药的 ST437。
Front Cell Infect Microbiol. 2024 Sep 11;14:1426817. doi: 10.3389/fcimb.2024.1426817. eCollection 2024.
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Isolation and characterization of two novel bacteriophages against carbapenem-resistant .分离并鉴定两株针对耐碳青霉烯肠杆菌科细菌的新型噬菌体
Front Cell Infect Microbiol. 2024 Aug 29;14:1421724. doi: 10.3389/fcimb.2024.1421724. eCollection 2024.
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Clinically relevant sequence types of carbapenemase-producing Escherichia coli and Klebsiella pneumoniae detected in Finnish wastewater in 2021-2022.2021-2022 年芬兰废水中检出的具有临床相关性的产碳青霉烯酶大肠埃希菌和肺炎克雷伯菌的序列型。
Antimicrob Resist Infect Control. 2024 Jan 30;13(1):14. doi: 10.1186/s13756-024-01370-z.
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Predominant transmission of KPC-2 carbapenemase in Germany by a unique IncN plasmid variant harboring a novel non-transposable element (NTE -Y).在德国，一种独特的 IncN 质粒变体携带一种新型非可转移元件（NTE-Y），主导了 KPC-2 碳青霉烯酶的传播。
Microbiol Spectr. 2024 Jan 11;12(1):e0256423. doi: 10.1128/spectrum.02564-23. Epub 2023 Dec 12.
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Plasmid genomic epidemiology of carbapenemase-producing in Canada, 2010-2021.2010-2021 年加拿大产碳青霉烯酶质粒基因组流行病学研究。
Antimicrob Agents Chemother. 2023 Dec 14;67(12):e0086023. doi: 10.1128/aac.00860-23. Epub 2023 Nov 16.
本文引用的文献
1
Molecular epidemiology of KPC-2- producing Klebsiella pneumoniae isolates in Brazil: the predominance of sequence type 437.巴西产 KPC-2 的肺炎克雷伯菌分离株的分子流行病学：优势序列型 437。
Diagn Microbiol Infect Dis. 2011 Jun;70(2):274-7. doi: 10.1016/j.diagmicrobio.2011.01.006. Epub 2011 Mar 11.
2
ST11, the dominant clone of KPC-producing Klebsiella pneumoniae in China.ST11，中国产 KPC 肺炎克雷伯菌的优势克隆。
J Antimicrob Chemother. 2011 Feb;66(2):307-12. doi: 10.1093/jac/dkq431. Epub 2010 Dec 3.
3
Emerging carbapenemases: a global perspective.新兴碳青霉烯酶：全球视角。
Int J Antimicrob Agents. 2010 Nov;36 Suppl 3:S8-14. doi: 10.1016/S0924-8579(10)70004-2.
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Escherichia coli producing KPC-2 carbapenemase: first report in Brazil.产KPC-2碳青霉烯酶的大肠埃希菌：巴西首例报告。
Diagn Microbiol Infect Dis. 2010 Nov;68(3):337-8. doi: 10.1016/j.diagmicrobio.2010.07.002. Epub 2010 Sep 17.
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Carbapenem Heteroresistance in VIM-1-producing Klebsiella pneumoniae isolates belonging to the same clone: consequences for routine susceptibility testing.产 VIM-1 肺炎克雷伯菌同克隆株碳青霉烯类药物异质性耐药：对常规药敏试验的影响。
J Clin Microbiol. 2010 Nov;48(11):4089-93. doi: 10.1128/JCM.01130-10. Epub 2010 Sep 15.
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Worldwide diversity of Klebsiella pneumoniae that produce beta-lactamase blaKPC-2 gene.产生 blaKPC-2 基因的产超广谱β-内酰胺酶肺炎克雷伯菌的全球多样性。
Emerg Infect Dis. 2010 Sep;16(9):1349-56. doi: 10.3201/eid1609.091389.
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Complete nucleotide sequence of KPC-3-encoding plasmid pKpQIL in the epidemic Klebsiella pneumoniae sequence type 258.KPC-3 编码质粒 pKpQIL 在流行的肺炎克雷伯菌序列型 258 中的完整核苷酸序列。
Antimicrob Agents Chemother. 2010 Oct;54(10):4493-6. doi: 10.1128/AAC.00175-10. Epub 2010 Aug 9.
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Sequence of pNL194, a 79.3-kilobase IncN plasmid carrying the blaVIM-1 metallo-beta-lactamase gene in Klebsiella pneumoniae.肺炎克雷伯菌 pNL194 质粒的序列分析，该质粒为大小为 79.3kb 的 IncN 型质粒，携带有 blaVIM-1 金属β-内酰胺酶基因。
Antimicrob Agents Chemother. 2010 Oct;54(10):4497-502. doi: 10.1128/AAC.00665-10. Epub 2010 Jul 26.
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Complete nucleotide sequence of the IncN plasmid pKOX105 encoding VIM-1, QnrS1 and SHV-12 proteins in Enterobacteriaceae from Bolzano, Italy compared with IncN plasmids encoding KPC enzymes in the USA.意大利博尔扎诺肠杆菌科中携带 VIM-1、QnrS1 和 SHV-12 蛋白的 IncN 质粒 pKOX105 的完整核苷酸序列与美国携带 KPC 酶的 IncN 质粒比较。
J Antimicrob Chemother. 2010 Oct;65(10):2070-5. doi: 10.1093/jac/dkq269. Epub 2010 Jul 22.
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Determinants of beta-lactam resistance in meningitis-causing Enterobacteriaceae in Brazil.巴西引起脑膜炎的肠杆菌科细菌中β-内酰胺类耐药的决定因素。
Can J Microbiol. 2010 May;56(5):399-407. doi: 10.1139/w10-020.
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