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blaKPC-2 通过肺炎克雷伯菌克隆群 258 克隆（ST258、ST11、ST437）和质粒（IncFII、IncN、IncL/M）在巴西肠杆菌科物种中的传播。

Dissemination of blaKPC-2 by the spread of Klebsiella pneumoniae clonal complex 258 clones (ST258, ST11, ST437) and plasmids (IncFII, IncN, IncL/M) among Enterobacteriaceae species in Brazil.

机构信息

Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirao Preto, Brazil.

出版信息

Antimicrob Agents Chemother. 2011 Jul;55(7):3579-83. doi: 10.1128/AAC.01783-10. Epub 2011 May 16.

DOI:10.1128/AAC.01783-10
PMID:21576442
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3122403/
Abstract

This article reports the spread of bla(KPC-2) in the Sao Paulo and Rio de Janeiro states, facilitated by globally spread K. pneumoniae clonal complex 258 (CC258) clones (ST258, ST11, and ST437) and a diversity of plasmids (IncFII, IncN, and IncL/M, two untypeable plasmids carrying Tn4401a or Tn4401b) successfully disseminated among species of the Enterobacteriaceae (Enterobacter cloacae, Serratia marcescens, and Citrobacter freundii). It also constitutes the first description of sequence type 258 (ST258) in Brazil, which was associated with a nosocomial hospital outbreak in Ribeirao Preto city.

摘要

这篇文章报道了 bla(KPC-2) 在圣保罗州和里约热内卢州的传播，这得益于全球传播的肺炎克雷伯菌克隆群 258（CC258）克隆（ST258、ST11 和 ST437）和多种质粒（IncFII、IncN 和 IncL/M，两个携带 Tn4401a 或 Tn4401b 的无法分型的质粒）在肠杆菌科（阴沟肠杆菌、粘质沙雷氏菌和弗氏柠檬酸杆菌）种间成功传播。它还首次描述了巴西的序列型 258（ST258），该型与里贝朗普雷图市的医院暴发有关。

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本文引用的文献

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ST11, the dominant clone of KPC-producing Klebsiella pneumoniae in China.ST11，中国产 KPC 肺炎克雷伯菌的优势克隆。
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Emerging carbapenemases: a global perspective.新兴碳青霉烯酶：全球视角。
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Carbapenem Heteroresistance in VIM-1-producing Klebsiella pneumoniae isolates belonging to the same clone: consequences for routine susceptibility testing.产 VIM-1 肺炎克雷伯菌同克隆株碳青霉烯类药物异质性耐药：对常规药敏试验的影响。
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