Lobo L L, Neumann B G, Eidman D S, Tufik S
Department of Psychobiology, Escola Paulista de Medicina, São Paulo, Brazil.
Pharmacology. 1990;40(3):174-8. doi: 10.1159/000138656.
Central administration of ACTH in rats induces yawning and stretching. In order to study the effects of REM sleep deprivation on ACTH-induced yawning, the peptide was injected immediately after the REM sleep deprivation period or 24 h later. REM sleep deprivation impaired ACTH-induced yawning, but after a 24-hour recovery period, rats displayed a number of yawns similar to those in control animals. Implications for an involvement of dopaminergic and mainly cholinergic systems are discussed.
给大鼠中枢注射促肾上腺皮质激素会诱发打哈欠和伸展身体。为了研究快速眼动睡眠剥夺对促肾上腺皮质激素诱发打哈欠的影响，在快速眼动睡眠剥夺期结束后或24小时后立即注射该肽。快速眼动睡眠剥夺会损害促肾上腺皮质激素诱发的打哈欠，但经过24小时的恢复期后，大鼠打哈欠的次数与对照动物相似。文中讨论了多巴胺能系统尤其是胆碱能系统参与其中的可能性。
