Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Opt Lett. 2011 May 15;36(10):1866-8. doi: 10.1364/OL.36.001866.
Linear polarization intrinsic optical signal (LP-IOS) measurement can provide sensitive detection of neural activities in stimulus-activated neural tissues. However, the LP-IOS magnitude and signal-to-noise ratio (SNR) are highly correlated with the nerve orientation relative to the polarization plane of the incident light. Because of the complexity of orientation dependency, LP-IOS optimization and outcome interpretation are time consuming and complicated. In this study, we demonstrate the feasibility of circular polarization intrinsic optical signal (CP-IOS) measurement. Our theoretical modeling and experimental investigation indicate that CP-IOS magnitude and SNR are independent from the nerve orientation. Therefore, CP-IOS promises a practical method for polarization IOS imaging of complex neural systems.
线性偏振固有光学信号（LP-IOS）测量可以提供对刺激激活的神经组织中神经活动的敏感检测。然而，LP-IOS 的幅度和信噪比（SNR）与神经相对于入射光偏振平面的方向密切相关。由于取向依赖性的复杂性，LP-IOS 的优化和结果解释既耗时又复杂。在这项研究中，我们展示了圆偏振固有光学信号（CP-IOS）测量的可行性。我们的理论建模和实验研究表明，CP-IOS 的幅度和 SNR 与神经方向无关。因此，CP-IOS 有望成为复杂神经系统偏振 IOS 成像的实用方法。
