Swiss Laboratory for Anti-Doping Analyses, Chemin des Croisettes, 1066 Lausanne, Switzerland.
Clin Chem. 2011 Jul;57(7):969-76. doi: 10.1373/clinchem.2011.162271. Epub 2011 May 19.
In elite sports, the growing availability of doping substances identical to those naturally produced by the human body seriously limits the ability of drug-testing regimes to ensure fairness and protection of health.
The Athlete Biological Passport (ABP), the new paradigm in testing based on the personalized monitoring of biomarkers of doping, offers the enormous advantage of being independent of this endless pharmaceutical race. Doping triggers physiological changes that provide physiological enhancements. In the same way that disease-related biomarkers are invaluable tools that assist physicians in the diagnosis of pathology, specifically selected biomarkers can be used to detect doping.
The ABP is a new testing paradigm with immense potential value in the current climate of rapid advancement in biomarker discovery. In addition to its original aim of providing proof of a doping offense, the ABP can also serve as a platform for a Rule of Sport, with the presentation before competition of the ABP to objectively demonstrate that the athlete will participate in a healthy physiological condition that is unaltered by performance-enhancing drugs. Finally, the decision-support system used today for the biological monitoring of world top-level athletes can also be advantageously transferred to other areas of clinical practice to reach the goal of personalized medicine.
在精英运动中，越来越多的与人体自然产生的兴奋剂物质相同的兴奋剂的出现，严重限制了药物测试制度确保公平和保护健康的能力。
运动员生物护照（ABP），基于兴奋剂生物标志物的个性化监测的新测试模式，具有独立于这种无休止的药物竞赛的巨大优势。兴奋剂会引发生理变化，从而提供生理增强。就像与疾病相关的生物标志物是协助医生诊断病理学的宝贵工具一样，专门选择的生物标志物可用于检测兴奋剂。
在当前生物标志物发现快速发展的背景下，ABP 是一种具有巨大潜在价值的新型测试模式。除了最初提供兴奋剂违规证据的目的外，ABP 还可以作为运动规则的平台，在比赛前呈现 ABP，客观证明运动员将以未受兴奋剂影响的健康生理状态参加比赛。最后，今天用于世界顶级运动员生物监测的决策支持系统也可以有利地转移到其他临床实践领域，以实现个性化医疗的目标。
