Department of Psychology, Institute of Psychiatry, King's College London, 5th Floor Bermondsey Wing, Guy's Hospital, London, SE1 9RT, UK.
J Neurol. 2011 Sep;258(9):1581-92. doi: 10.1007/s00415-011-6062-5. Epub 2011 May 20.
We reviewed the literature on how muscle disease affects quality of life compared to healthy controls, and the factors that influence the effects of muscle disease on quality of life. We also wanted to know whether quality of life differed between muscle diseases. We searched online databases and identified 26 relevant studies. The quality of each study was assessed, results sections analysed and a database of factors associated with quality of life developed. We graded the level of evidence supporting the association between each factor and quality of life as inconclusive, moderate or high. Compared to controls, muscle disease compromised quality of life in all areas of functioning. There was little evidence to suggest that quality of life differed significantly between muscle diseases. There was a high level of evidence suggesting that disease severity, pain, fatigue, and mood significantly affect quality of life. There was a moderate level of evidence suggesting that illness perceptions, coping strategies, age and gender affect quality of life. Several factors had an inconsistent level of evidence.
我们回顾了肌肉疾病对生活质量的影响与健康对照组相比的文献，以及影响肌肉疾病对生活质量影响的因素。我们还想知道肌肉疾病之间的生活质量是否存在差异。我们在在线数据库中进行了检索，确定了 26 项相关研究。评估了每项研究的质量，分析了结果部分，并开发了一个与生活质量相关的因素数据库。我们将每个因素与生活质量之间关联的证据水平评为不确定、中等或高。与对照组相比，肌肉疾病在所有功能领域都损害了生活质量。几乎没有证据表明肌肉疾病之间的生活质量有显著差异。有高水平的证据表明，疾病严重程度、疼痛、疲劳和情绪显著影响生活质量。有中等水平的证据表明，疾病认知、应对策略、年龄和性别影响生活质量。一些因素的证据水平不一致。
