Doycheva Iliana, Chen Chaoru, Pan Jen-Jung, Levy Cynthia
Iliana Doycheva, Department of Medicine, University of Florida, Gainesville, FL 32610, United States.
World J Hepatol. 2011 Apr 27;3(4):93-8. doi: 10.4254/wjh.v3.i4.93.
To estimate the prevalence of cardiovascular events in Primary biliary cirrhosis (PBC) and to determine whether this risk is higher within specific subgroups of patients with PBC.
We included 180 patients with PBC (cases) and 151 patients seen for HCV infection (controls). Medical records were reviewed and statistical analyses were performed as appropriate.
When compared to controls, PBC patients were older, leaner and had higher serum levels of total cholesterol, high density lipoprotein and low density cholesterol. There were more females in the PBC group (91.7% vs 43%, P < 0.001). More control subjects had smoked than the PBC patients (63.6% vs 35%, P < 0.001). The prevalence of hypertension, diabetes, coronary artery disease and stroke was similar between the two groups. Seven percent of controls and 10% of cases developed any type of cardiovascular disease (P = 0.3). Only 36.7% were asymptomatic at diagnosis. Three cardiovascular events were documented among asymptomatic patients (4.5%) and fifteen among symptomatic patients (13.2%; P = 0.06). Among PBC patients with fatigue, 10 (13.5%) had a cardiovascular event compared to 7 (6.7%) among patients without fatigue (P = 0.1).
Asymptomatic PBC patients do not have a greater frequency of cardiovascular disease; nor do patients suffering with fatigue.
评估原发性胆汁性肝硬化（PBC）患者心血管事件的患病率，并确定在PBC患者的特定亚组中该风险是否更高。
我们纳入了180例PBC患者（病例组）和151例丙型肝炎病毒感染患者（对照组）。查阅病历并进行适当的统计分析。
与对照组相比，PBC患者年龄更大、体型更瘦，血清总胆固醇、高密度脂蛋白和低密度胆固醇水平更高。PBC组女性更多（91.7%对43%，P<0.001）。吸烟的对照组患者比PBC患者更多（63.6%对35%，P<0.001）。两组间高血压、糖尿病、冠状动脉疾病和中风患病率相似。7%的对照组患者和10%的病例组患者发生了任何类型的心血管疾病（P=0.3）。仅36.7%的患者在诊断时无症状。无症状患者中有三例发生心血管事件（4.5%）；有症状患者中有15例（13.2%；P=0.06）。在有疲劳症状 的PBC患者中，10例（13.5%）发生了心血管事件，而无疲劳症状的患者中有7例（6.7%）发生心血管事件（P=0.1）。
无症状的PBC患者发生心血管疾病频率并不更高；有疲劳症状的患者也是如此。
