Key Laboratory of Chemical Safety and Health, National Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, No. 29, Nanwei Road, Beijing, 100050, China.
Environ Int. 2011 Oct;37(7):1206-12. doi: 10.1016/j.envint.2011.05.001. Epub 2011 May 26.
Perfluorinated compounds (PFCs) are worldwide present in the environment and the general population. Animal studies have shown developmental toxicity of these compounds. To investigate the PFCs exposure of neonates from mother during gestation and lactation, we analyzed twelve PFCs in matched maternal serum, cord serum and breast milk samples collected from 50 pairs of women and their newborns between June and July 2009 in Jinhu, China. Eight PFCs were detected in serum samples, and five of them were also detectable in breast milk. A significant intercorrelation between PFCs concentrations in matched maternal serum, cord serum and breast milk was observed (p<0.01, r=0.435-0.911). The median partition ratio was from 0.39:1 (PFDA) to 1.74:1 (PFTrDA) for seven PFCs through the placenta, and was from 0.02:1 (PFOS) to 0.09:1 (PFOA) for five PFCs through the lactation. A high transport efficiency of PFOA both through placental barrier and lactation was observed. The postnatal exposure of PFCs through lactation was higher compared to prenatal exposure, especially for PFOA.
全氟化合物（PFCs）在全球范围内存在于环境和人群中。动物研究表明这些化合物具有发育毒性。为了研究围孕期和哺乳期母亲向新生儿的 PFCs 暴露情况，我们分析了 2009 年 6 月至 7 月间在中国金湖采集的 50 对母婴配对的血清、脐带血清和母乳样本中的 12 种 PFCs。在血清样本中检测到了 8 种 PFCs，其中 5 种也可在母乳中检测到。在匹配的母血清、脐血清和母乳中 PFCs 浓度之间观察到显著的相关性（p<0.01，r=0.435-0.911）。通过胎盘的 7 种 PFCs 的中位数分配比为 0.39:1（PFDA）至 1.74:1（PFTrDA），而通过哺乳的 5 种 PFCs 的中位数分配比为 0.02:1（PFOS）至 0.09:1（PFOA）。PFOA 具有较高的胎盘屏障和哺乳传递效率。与产前暴露相比，通过哺乳的新生儿 PFCs 暴露在产后更高，特别是 PFOA。
