Laboratory of Muscle Stem Cell and Gene Regulation, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda, Maryland, USA.
Curr Top Dev Biol. 2011;96:57-83. doi: 10.1016/B978-0-12-385940-2.00003-6.
Satellite cells (SCs) are the main source of adult skeletal muscle stem cells responsible for muscle growth and regeneration. By interpreting extracellular cues, developmental regulators control quiescence, proliferation, and differentiation of SCs by influencing coordinate gene expression. The scope of this review is limited to the description and discussion of protein complexes that introduce and decode heritable histone and chromatin modifications and how these modifications are relevant for SC biology.
卫星细胞 (SCs) 是成年骨骼肌干细胞的主要来源，负责肌肉生长和再生。通过解读细胞外信号，发育调控因子通过影响协调的基因表达来控制 SC 的静止、增殖和分化。本综述的范围仅限于描述和讨论引入和解码可遗传组蛋白和染色质修饰的蛋白质复合物，以及这些修饰如何与 SC 生物学相关。
