Cajal间质细胞：肠易激综合征病理生理学的新假说
Interstitial cells of Cajal: a novel hypothesis for the pathophysiology of irritable bowel syndrome.
作者信息
Eshraghian Ahad, Eshraghian Hamed
机构信息
Department of Internal Medicine, Shiraz University of Medical Science, Shiraz, Fars Province, Iran.
出版信息
Can J Gastroenterol. 2011 May;25(5):277-9. doi: 10.1155/2011/478370.
Abstract
Irritable bowl syndrome (IBS) affects a large proportion of the world's population, and accounts for a considerable number of visits to gastroenterologists and general practitioners. Despite its high prevalence, the precise mechanism of IBS has not been identified to date. The interstitial cells of Cajal (ICC) participate in the production of slow waves and the regulation of their propagation through the gastrointestinal system; thus, they are important components of gastrointestinal motility. The present review proposes that ICC play a central role in the pathophysiology of IBS. This hypothesis is based on many links between ICC and currently proposed mechanisms of IBS pathophysiology. It appears that ICC may be involved in almost all of the previously explained pathogenic mechanisms of IBS. If proven, this hypothesis may provide a key to solving the IBS mystery.
摘要
肠易激综合征（IBS）影响着世界上很大一部分人口，并且导致大量患者就诊于胃肠病学家和全科医生处。尽管其患病率很高，但迄今为止，IBS的确切机制尚未明确。 Cajal间质细胞（ICC）参与慢波的产生及其在整个胃肠系统中的传播调节；因此，它们是胃肠动力的重要组成部分。本综述提出，ICC在IBS的病理生理学中起核心作用。这一假设基于ICC与目前提出的IBS病理生理学机制之间的许多联系。似乎ICC可能几乎参与了先前解释的IBS所有致病机制。如果这一假设得到证实，可能为解开IBS之谜提供关键线索。
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