Max Planck Institute of Biochemistry, Organelle Architecture and Dynamics, Martinsried, Germany.
Nat Struct Mol Biol. 2011 Jun 19;18(7):854-6. doi: 10.1038/nsmb.2080.
Plasma membranes are organized into domains of different protein and lipid composition. Eisosomes are key complexes for yeast plasma membrane organization, containing primarily Pil1 and Lsp1. Here we show that both proteins consist mostly of a banana-shaped BAR domain common to membrane sculpting proteins, most similar to the ones of amphiphysin, arfaptin 2 and endophilin 2. Our data reveal a previously unrecognized family of BAR-domain proteins involved in plasma membrane organization.
质膜组织成不同蛋白质和脂质组成的域。Eisosomes 是酵母质膜组织的关键复合物，主要包含 Pil1 和 Lsp1。在这里，我们表明这两种蛋白质主要由一个香蕉形 BAR 结构域组成，该结构域与膜成型蛋白共同存在，与 amphiphysin、arfaptin 2 和 endophilin 2 的结构域最为相似。我们的数据揭示了一个以前未被识别的 BAR 结构域蛋白家族，它们参与了质膜的组织。
