J. Allyn Taylor Centre for Cell Biology, Molecular Brain Research Group, Robarts Research Institute, London, ON, CanadaThe Department of Physiology & Pharmacology, the University of Western Ontario, London, ON, Canada.
Br J Pharmacol. 2012 Mar;165(6):1717-1736. doi: 10.1111/j.1476-5381.2011.01552.x.
GPCRs represent the largest family of integral membrane proteins and were first identified as receptor proteins that couple via heterotrimeric G-proteins to regulate a vast variety of effector proteins to modulate cellular function. It is now recognized that GPCRs interact with a myriad of proteins that not only function to attenuate their signalling but also function to couple these receptors to heterotrimeric G-protein-independent signalling pathways. In addition, intracellular and transmembrane proteins associate with GPCRs and regulate their processing in the endoplasmic reticulum, trafficking to the cell surface, compartmentalization to plasma membrane microdomains, endocytosis and trafficking between intracellular membrane compartments. The present review will overview the functional consequence of β-arrestin, receptor activity-modifying proteins (RAMPS), regulators of G-protein signalling (RGS), GPCR-associated sorting proteins (GASPs), Homer, small GTPases, PSD95/Disc Large/Zona Occludens (PDZ), spinophilin, protein phosphatases, calmodulin, optineurin and Src homology 3 (SH3) containing protein interactions with GPCRs.
G 蛋白偶联受体（GPCRs）是最大的跨膜蛋白家族，最初被鉴定为通过异源三聚体 G 蛋白偶联的受体蛋白，以调节各种效应蛋白来调节细胞功能。现在人们已经认识到，GPCR 与许多蛋白质相互作用，这些蛋白质不仅可以减弱它们的信号，还可以将这些受体与异源三聚体 G 蛋白非依赖性信号通路偶联。此外，细胞内和跨膜蛋白与 GPCR 结合，并调节它们在内质网中的加工、向细胞表面的运输、向质膜微区室的区室化、内吞作用以及细胞内膜隔室之间的运输。本综述将概述β-arrestin、受体活性修饰蛋白（RAMPS）、G 蛋白信号调节因子（RGS）、GPCR 相关分选蛋白（GASPs）、 Homer、小 GTPases、PSD95/Disc Large/Zona Occludens（PDZ）、spinophilin、蛋白磷酸酶、钙调蛋白、optineurin 和 SRC 同源 3（SH3）与 GPCR 相互作用的功能后果。
