Centre de Recherche sur la Cognition Animale, UMR CNRS 5169, Université Paul-Sabatier, Toulouse, France.
Gerontology. 2012;58(2):126-8. doi: 10.1159/000328675. Epub 2011 Jun 24.
Dietary restriction (DR: food restriction without malnutrition) is often considered as a nearly universal means to extend longevity in animal species and we could make the hypothesis that DR could increase longevity in humans. Some authors support the opinion that DR has already increased longevity in Okinawa inhabitants, and thus that DR can increase longevity in humans. The purpose of this article is to stress that no data on humans with a normal body mass index (neither overweight nor obese) indicate that DR can increase life span and health span, particularly because the results observed in Okinawa inhabitants can probably be considered as showing mainly deleterious effects of malnutrition rather than positive effects of DR. Since DR does not appear to increase human life span, studies testing for the effect of DR in humans should focus on the health effects of a mild DR in overweight and obese people, rather than in normal-weight people.
饮食限制（DR：不导致营养不良的节食）通常被认为是延长动物寿命的一种普遍手段，我们可以假设 DR 可以延长人类的寿命。一些作者支持这样的观点，即 DR 已经延长了冲绳居民的寿命，因此 DR 可以延长人类的寿命。本文的目的是强调，没有任何数据表明正常体重指数（既不超重也不肥胖）的人类通过 DR 可以延长寿命和健康寿命，特别是因为在冲绳居民中观察到的结果可能主要是营养不良的有害影响，而不是 DR 的积极影响。由于 DR 似乎不会延长人类的寿命，因此在人类中测试 DR 效果的研究应该集中在轻度 DR 对超重和肥胖人群的健康影响上，而不是在体重正常的人群上。
