鼻咽癌的早期检测
Early detection of nasopharyngeal carcinoma.
作者信息
Tabuchi Keiji, Nakayama Masahiro, Nishimura Bungo, Hayashi Kentaro, Hara Akira
机构信息
Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, 1-1-1 Tennodai, Tsukuba 305-8575, Japan.
出版信息
Int J Otolaryngol. 2011;2011:638058. doi: 10.1155/2011/638058. Epub 2011 Jun 8.
Abstract
Nasopharyngeal carcinoma (NPC) is a unique disease with a clinical presentation, epidemiology, and histopathology differing from other squamous cell carcinomas of the head and neck. NPC is an Epstein-Barr virus-associated malignancy with a marked racial and geographic distribution. Specifically, it is highly prevalent in southern China, Southeast Asia, and the Middle East. To date, most NPC patients have been diagnosed in the advanced stage, but the treatment results for advanced NPC are not satisfactory. This paper provides a brief overview regarding NPC, with the focus on the early detection of initial and recurrent NPC lesions.
摘要
鼻咽癌（NPC）是一种独特的疾病，其临床表现、流行病学和组织病理学与头颈部其他鳞状细胞癌不同。NPC是一种与爱泼斯坦-巴尔病毒相关的恶性肿瘤，具有明显的种族和地理分布。具体而言，它在中国南方、东南亚和中东地区高度流行。迄今为止，大多数NPC患者在晚期才被诊断出来，但晚期NPC的治疗效果并不理想。本文简要概述了NPC，重点是早期发现初发和复发性NPC病变。
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本文引用的文献
1
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Radiology. 2011 Feb;258(2):531-7. doi: 10.1148/radiol.10101241. Epub 2010 Dec 3.
2
Identification of Galectin-1 as a novel biomarker in nasopharyngeal carcinoma by proteomic analysis.蛋白质组学分析鉴定 Galectin-1 为鼻咽癌的一种新型生物标志物。
Oncol Rep. 2010 Aug;24(2):495-500.
3
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.全基因组关联研究发现鼻咽癌三个新的易感性位点。
Nat Genet. 2010 Jul;42(7):599-603. doi: 10.1038/ng.601. Epub 2010 May 30.
4
Identification of candidate nasopharyngeal carcinoma serum biomarkers by cancer cell secretome and tissue transcriptome analysis: potential usage of cystatin A for predicting nodal stage and poor prognosis.通过癌细胞分泌组和组织转录组分析鉴定鼻咽癌候选血清标志物：胱抑素 A 预测淋巴结分期和预后不良的潜在用途。
Proteomics. 2010 Jul;10(14):2644-60. doi: 10.1002/pmic.200900620.
5
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6
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Ann Otol Rhinol Laryngol. 2010 Feb;119(2):77-81. doi: 10.1177/000348941011900202.
7
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Am J Hum Genet. 2009 Aug;85(2):194-203. doi: 10.1016/j.ajhg.2009.07.007. Epub 2009 Aug 6.
10
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Head Neck. 2009 Oct;31(10):1309-15. doi: 10.1002/hed.21091.
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