Norkin L C, Einck K H
Antimicrob Agents Chemother. 1978 Dec;14(6):930-2. doi: 10.1128/AAC.14.6.930.
Treatment of CV-1 cells with chloroquine before infection by simian virus 40 resulted in the accumulation of fewer nonviable, trypan blue-stainable cells at 72 h. The drug did not affect the fraction of infected T-antigen-producing cells or the viral yields. It did diminish the apparent redistribution of lysosomal N-acetyl-beta-glucosaminidase from a particulate to a soluble cell fraction, and it caused an increase in the size and number of lysosomes.
在感染猿猴病毒40之前，用氯喹处理CV - 1细胞，结果在72小时时，不可存活的、台盼蓝可染色的细胞积累较少。该药物不影响被感染的产生T抗原细胞的比例或病毒产量。它确实减少了溶酶体N - 乙酰 - β - 氨基葡萄糖苷酶从颗粒状到可溶性细胞组分的明显重新分布，并且它导致溶酶体的大小和数量增加。
