Cell killing by Simian virus 40: protective effect of chloroquine.
作者信息
Norkin L C, Einck K H
出版信息
Antimicrob Agents Chemother. 1978 Dec;14(6):930-2. doi: 10.1128/AAC.14.6.930.
Abstract
Treatment of CV-1 cells with chloroquine before infection by simian virus 40 resulted in the accumulation of fewer nonviable, trypan blue-stainable cells at 72 h. The drug did not affect the fraction of infected T-antigen-producing cells or the viral yields. It did diminish the apparent redistribution of lysosomal N-acetyl-beta-glucosaminidase from a particulate to a soluble cell fraction, and it caused an increase in the size and number of lysosomes.
摘要
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