Department of Psychological Medicine, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Drug Alcohol Rev. 2012 May;31(3):327-33. doi: 10.1111/j.1465-3362.2011.00339.x. Epub 2011 Jul 6.
To examine the associations between substance abuse/dependence symptoms and life satisfaction, before and after adjustment for fixed and time-dynamic sources of confounding.
Data were drawn from a 30year longitudinal study of a birth cohort of 987 individuals. Associations between alcohol abuse/dependence symptoms, cannabis abuse/dependence symptoms and life satisfaction were examined using repeated measures regression models. Associations were adjusted for fixed and time-dynamic sources of confounding, including family background, personality, demographics, recent life events, current employment and recent mental illness.
There were significant associations between alcohol abuse/dependence and life satisfaction (P<0.0001) and between cannabis abuse/dependence and life satisfaction (P<0.0001). These significant associations remained after adjustment for fixed sources of confounding. However, adjusting for time-dynamic sources of confounding substantially reduced the associations. After adjustment for time-dynamic sources of confounding there were no significant associations between alcohol abuse/dependence and life satisfaction (P>0.17) or cannabis abuse/dependence and life satisfaction (P>0.25).
These findings suggest that associations between life substance abuse/dependence and life satisfaction can be explained by time-dynamic factors, such as employment, life events and comorbid mental illness that are associated with reduced life satisfaction. When due allowance is made for confounding, alcohol and cannabis abuse/dependence are not associated with reduced life satisfaction.
在调整固定和时变混杂来源后,检查物质滥用/依赖症状与生活满意度之间的关联。
数据来自对 987 名出生队列的 30 年纵向研究。使用重复测量回归模型检查酒精滥用/依赖症状、大麻滥用/依赖症状与生活满意度之间的关联。关联调整了固定和时变混杂来源,包括家庭背景、个性、人口统计学、近期生活事件、当前就业和近期精神疾病。
酒精滥用/依赖与生活满意度之间存在显著关联(P<0.0001),大麻滥用/依赖与生活满意度之间也存在显著关联(P<0.0001)。在调整固定混杂来源后,这些显著关联仍然存在。然而,调整时变混杂来源大大降低了关联。在调整时变混杂来源后,酒精滥用/依赖与生活满意度之间没有显著关联(P>0.17)或大麻滥用/依赖与生活满意度之间没有显著关联(P>0.25)。
这些发现表明,生活物质滥用/依赖与生活满意度之间的关联可以用时间动态因素来解释,例如与生活满意度降低相关的就业、生活事件和合并精神疾病。在适当考虑混杂因素后,酒精和大麻滥用/依赖与生活满意度降低无关。