Department of Clinical and Biological Sciences, Oral Medicine and Oral Oncology Section, University of Turin, Turin, Italy.
J Oral Pathol Med. 2010 Sep;39(8):611-6. doi: 10.1111/j.1600-0714.2010.00922.x. Epub 2010 Aug 3.
To compare different therapeutic supportive approaches in patients with burning mouth syndrome. A prospective study was carried out for this purpose.
The study involved 56 patients with burning mouth syndrome. They were randomly assigned to treatment with capsaicin, alpha-lipoic acid or lysozyme-lactoperoxidase (test drugs) or boric acid (control group). Symptoms were scored after 60 days treatment and 60 days after drug discontinuation.
At the end of the treatment period, there was a significant reduction in the symptom scores of all of the patients who received the test drugs (P<0.01), and at the end of the follow-up period in the test groups as a whole (P<0.01); the reduction was not significant when considering each test group separately after the treatment period. All of the treatments were more effective than boric acid and there was no significant difference in the symptom scores of the control group at either of the study time-points.
Our results demonstrate the similar effectiveness of capsaicin and alpha-lipoic acid in controlling the symptoms of burning mouth syndrome. Lysozyme-lactoperoxidase may be effective in the supportive care of BMS patients with xerostomia. The transitory effect observed after discontinuing drug administration justifies the use of prolonged therapy in chronically affected patients.
为了比较不同治疗支持方法在灼口综合征患者中的疗效。为此进行了一项前瞻性研究。
本研究纳入了 56 例灼口综合征患者。他们被随机分配接受辣椒素、α-硫辛酸或溶菌酶-乳过氧化物酶（试验药物）或硼酸（对照组）治疗。治疗 60 天后和停药 60 天后对症状进行评分。
治疗结束时，所有接受试验药物治疗的患者的症状评分均显著降低（P<0.01），整个试验组在随访结束时也显著降低（P<0.01）；治疗结束后单独考虑每个试验组时，降低不显著。所有治疗均优于硼酸，且对照组在两个研究时间点的症状评分均无显著差异。
我们的结果表明辣椒素和α-硫辛酸在控制灼口综合征症状方面具有相似的疗效。溶菌酶-乳过氧化物酶可能对口干的 BMS 患者的支持治疗有效。停药后观察到的短暂效应证明了在慢性发病患者中使用长期治疗的合理性。
