ESKAPE 病原体中抗菌药物耐药性的表型和基因型检测方法（综述）
Phenotypic and genotypic detection methods for antimicrobial resistance in ESKAPE pathogens (Review).
作者信息
Muntean Mădălina Maria, Muntean Andrei-Alexandru, Preda Mădălina, Manolescu Loredana Sabina Cornelia, Dragomirescu Cerasella, Popa Mircea-Ioan, Popa Gabriela Loredana
机构信息
Department of Microbiology, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.
National Center of Expertise and Intervention in Public Health for Biological, Chemical, Radiological and Nuclear Agents, 'Cantacuzino' National Military Medical Institute for Research and Development, 050096 Bucharest, Romania.
出版信息
Exp Ther Med. 2022 Jun 9;24(2):508. doi: 10.3892/etm.2022.11435. eCollection 2022 Aug.
Antimicrobial resistance (AMR) represents a growing public health problem worldwide. Infections with such bacteria lead to longer hospitalization times, higher healthcare costs and greater morbidity and mortality. Thus, there is a greater need for rapid detection methods in order to limit their spread. The ESKAPE pathogens (, , , , and spp.) are a series of epidemiologically-important microorganisms of great concern due to their high levels of resistance. This review aimed to update the background information on the ESKAPE pathogens as well as to provide a summary of the numerous phenotypic and molecular methods used to detect their AMR mechanisms. While they are usually linked to hospital acquired infections, AMR is also spreading in the veterinary and the environmental sectors. Yet, the epidemiological loop closes with patients which, when infected with such pathogens, often lack therapeutic options. Thus, it was aimed to give the article a One Health perspective.
抗菌药物耐药性（AMR）在全球范围内是一个日益严重的公共卫生问题。感染此类细菌会导致住院时间延长、医疗成本增加以及更高的发病率和死亡率。因此，为了限制它们的传播，对快速检测方法的需求更为迫切。ESKAPE病原体（粪肠球菌、金黄色葡萄球菌、肺炎克雷伯菌、鲍曼不动杆菌、铜绿假单胞菌和阴沟肠杆菌）是一系列在流行病学上具有重要意义的微生物，因其高度耐药性而备受关注。本综述旨在更新关于ESKAPE病原体的背景信息，并总结用于检测其AMR机制的众多表型和分子方法。虽然它们通常与医院获得性感染有关，但AMR也正在兽医和环境领域传播。然而，当患者感染此类病原体时，往往缺乏治疗选择，流行病学循环由此闭合。因此，本文旨在从“同一健康”的角度进行阐述。
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