Wang Xuan-Yi, Kilgore Paul E, Lim Kyung Ah, Wang Song-Mei, Lee Jeongseok, Deng Wei, Mo Mei-Qi, Nyambat Batmunkh, Ma Jing-Chen, Favorov Michael O, Clemens John D
Center for Public Health and Infectious Disease, Institutes of Biomedical Sciences, Fudan University, 138 Yi Xue Yuan Road, Shanghai 200032, China.
Interdiscip Perspect Infect Dis. 2011;2011:146376. doi: 10.1155/2011/146376. Epub 2011 May 11.
To help understand the potential impact of bacterial coinfection during pandemic influenza periods, we undertook a far-reaching review of the existing literature to gain insights into the interaction of influenza and bacterial pathogens. Reports published between 1950 and 2006 were identified from scientific citation databases using standardized search terms. Study outcomes related to coinfection were subjected to a pooled analysis. Coinfection with influenza and bacterial pathogens occurred more frequently in pandemic compared with seasonal influenza periods. The most common bacterial coinfections with influenza virus were due to S. pneumoniae, H. influenzae, Staphylococcus spp., and Streptococcus spp. Of these, S. pneumoniae was the most common cause of bacterial coinfection with influenza and accounted for 40.8% and 16.6% of bacterial coinfections during pandemic and seasonal periods, respectively. These results suggest that bacterial pathogens will play a key role in many countries, as the H1N1(A) influenza pandemic moves forward. Given the role of bacterial coinfections during influenza epidemics and pandemics, the conduct of well-designed field evaluations of public health measures to reduce the burden of these common bacterial pathogens and influenza in at-risk populations is warranted.
为了帮助理解大流行性流感期间细菌合并感染的潜在影响，我们对现有文献进行了广泛回顾，以深入了解流感与细菌病原体之间的相互作用。使用标准化检索词从科学引文数据库中识别出1950年至2006年间发表的报告。对与合并感染相关的研究结果进行了汇总分析。与季节性流感时期相比，大流行性流感期间流感与细菌病原体的合并感染更为常见。与流感病毒合并感染的最常见细菌是肺炎链球菌、流感嗜血杆菌、葡萄球菌属和链球菌属。其中，肺炎链球菌是流感合并细菌感染的最常见原因，在大流行和季节性流感期间分别占合并细菌感染的40.8%和16.6%。这些结果表明，随着甲型H1N1流感大流行的发展，细菌病原体将在许多国家发挥关键作用。鉴于细菌合并感染在流感流行和大流行期间所起的作用，有必要对公共卫生措施进行精心设计的现场评估，以减轻高危人群中这些常见细菌病原体和流感的负担。
