Center for Oral Health Research, College of Dentistry, University of Kentucky, Lexington 40536-0305, USA.
Oral Dis. 2012 Jan;18(1):16-31. doi: 10.1111/j.1601-0825.2011.01830.x. Epub 2011 Jul 13.
A reduction in calorie intake [caloric restriction (CR)] appears to consistently decrease the biological rate of aging in a variety of organisms as well as protect against age-associated diseases including chronic inflammatory disorders such as cardiovascular disease and diabetes. Although the mechanisms behind this observation are not fully understood, identification of the main metabolic pathways affected by CR has generated interest in finding molecular targets that could be modulated by CR mimetics. This review describes the general concepts of CR and CR mimetics as well as discusses evidence related to their effects on inflammation and chronic inflammatory disorders. Additionally, emerging evidence related to the effects of CR on periodontal disease in non-human primates is presented. While the implementation of this type of dietary intervention appears to be challenging in our modern society where obesity is a major public health problem, CR mimetics could offer a promising alternative to control and perhaps prevent several chronic inflammatory disorders including periodontal disease.
热量摄入减少（热量限制）似乎能持续降低各种生物的生物学衰老速度，并预防与年龄相关的疾病，包括心血管疾病和糖尿病等慢性炎症性疾病。尽管这一观察结果的背后机制尚未完全阐明，但确定受到热量限制影响的主要代谢途径，引发了人们对寻找可通过热量限制类似物调节的分子靶标的兴趣。本文描述了热量限制和热量限制类似物的一般概念，并讨论了它们对炎症和慢性炎症性疾病的影响的相关证据。此外，还介绍了有关热量限制对非人类灵长类动物牙周病影响的新证据。虽然在肥胖是一个主要公共卫生问题的现代社会中实施这种饮食干预似乎具有挑战性，但热量限制类似物可能为控制甚至预防几种慢性炎症性疾病（包括牙周病）提供一个有前途的替代方法。
