眼球玻璃体随年龄增长产生的扩散变化。
Diffusion changes in the vitreous humor of the eye during aging.
机构信息
Department of Radiology, Kirikkale Universitesi Medicine Faculty, Turkey.
出版信息
AJNR Am J Neuroradiol. 2011 Sep;32(8):1563-6. doi: 10.3174/ajnr.A2543. Epub 2011 Jul 14.
BACKGROUND AND PURPOSE
The inability to image the vitreous humor of the eye adequately hinders a complete understanding of its normal structure and the changes occurring in aging and disease. The purpose of the present study was to reveal normative data and age-related changes of the vitreous humor by using DWI.
MATERIALS AND METHODS
A total of 160 patients were enrolled in the present study. Patients were divided into 8 groups according to decade of age, and each group was of equal size with 20 patients. The ADCs were determined for each vitreous humor. Each determination was obtained by using average regions of interest of 50 ± 2 mm(2). ADC values were then plotted against age.
RESULTS
The ADC values obtained from group 0 (0-10 years of age) were statistically different from those of all other groups (P < .05). Group 1 (11-20 years of age) was statistically different from groups 3, 5, 6, and 7 (P < .05). A trend toward increased ADC values with increasing age was not statistically significant.
CONCLUSIONS
Besides the statistically significant difference between pediatric and adult patients, a statistically insignificant trend of increased ADC values among aging adults has been demonstrated. These normative data contribute to our understanding of how DWI can aid in the diagnosis of age-related changes in eye health and function.
背景与目的
玻璃体无法充分成像严重阻碍了对其正常结构以及衰老和疾病过程中发生的变化的全面理解。本研究旨在通过 DWI 揭示玻璃体的正常数据和与年龄相关的变化。
材料与方法
本研究共纳入 160 例患者。患者根据年龄的十年进行分组，每组均为 20 例，每组大小相等。确定每个玻璃体的 ADC 值。通过使用 50 ± 2mm² 的平均感兴趣区域进行每个确定。然后将 ADC 值与年龄相关联。
结果
组 0（0-10 岁）的 ADC 值与所有其他组的 ADC 值存在统计学差异（P<.05）。组 1（11-20 岁）与组 3、5、6 和 7 存在统计学差异（P<.05）。年龄增长时 ADC 值增加的趋势无统计学意义。
结论
除了儿科患者与成年患者之间的统计学显著差异外，还显示了成年患者中 ADC 值增加的无统计学意义的趋势。这些正常数据有助于我们了解 DWI 如何有助于诊断与年龄相关的眼部健康和功能变化。
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