Department of Epidemiology, Joseph P. Mailman School of Public Health, Columbia University, 630 West 168th St., New York, NY 10032, USA.
Dement Geriatr Cogn Disord. 2011;31(6):424-30. doi: 10.1159/000324134. Epub 2011 Jul 15.
BACKGROUND/AIMS: To confirm in a cohort recruited in 1999-2001 our finding in a cohort recruited in 1992-1994 relating type 2 diabetes (T2D) to late-onset Alzheimer's disease (LOAD).
Participants were 1,488 persons aged 65 years and older without dementia at baseline from New York City. T2D was ascertained by self-report. Dementia and LOAD were ascertained by standard research procedures. Proportional hazard regression was used for analyses relating T2D and LOAD.
The prevalence of T2D was 17%. There were 161 cases of dementia and 149 cases of LOAD. T2D was related to dementia (hazard ratio = 1.7; 95% confidence interval = 1.4-2.9) and LOAD (1.6; 1.0-2.6) after adjustment for age, sex, education, ethnic group and apolipoprotein E ε4. This association was weaker when only AD - excluding cases of mixed dementia - was considered (hazard ratio = 1.3; 95% confidence interval = 0.8-2.2).
T2D is associated with LOAD. Cerebrovascular disease may be an important mediator.
背景/目的：在 1999-2001 年招募的队列中证实我们在 1992-1994 年招募的队列中的发现，即 2 型糖尿病（T2D）与晚发性阿尔茨海默病（LOAD）有关。
参与者是来自纽约市的 1488 名年龄在 65 岁及以上且基线时无痴呆的人。T2D 通过自我报告确定。痴呆症和 LOAD 通过标准研究程序确定。使用比例风险回归分析 T2D 与 LOAD 的关系。
T2D 的患病率为 17%。有 161 例痴呆症和 149 例 LOAD。调整年龄、性别、教育程度、族裔和载脂蛋白 E ε4 后，T2D 与痴呆症（危险比=1.7；95%置信区间=1.4-2.9）和 LOAD（1.6；1.0-2.6）有关。当仅考虑 AD（排除混合性痴呆病例）时，这种关联较弱（危险比=1.3；95%置信区间=0.8-2.2）。
T2D 与 LOAD 有关。脑血管疾病可能是一个重要的中介因素。
