Department of Medicinal Chemistry, Pharmaceutical University, Nanjing 210009, China.
Mini Rev Med Chem. 2011 Sep;11(10):910-9. doi: 10.2174/138955711796575416.
The ent-kaurane diterpenoids are widely distributed in China, some of which have high natural abundance in plants of Isodon, Pteris, Gnaphalium, Diplospora, Croton and some other species. These compounds exhibit significant anti-tumor, antibacterial and anti-inflammatory activities, which have attracted the attention of medicinal chemists. This review focuses on the recent advances in the research of derivatives, anti-tumor activity, mechanism of action, and structure-activity relationships of ent-kaurane diterpenoids. All of these will show the potential in the development of new antitumor agents in natural products.
环二萜类化合物广泛分布于中国，其中一些在 Isodon、Pteris、Gnaphalium、Diplospora、Croton 和其他一些物种的植物中具有较高的天然丰度。这些化合物具有显著的抗肿瘤、抗菌和抗炎活性，引起了药物化学家的关注。本综述重点介绍了近年来对环二萜类化合物的衍生物、抗肿瘤活性、作用机制和构效关系的研究进展。所有这些都将展示天然产物中开发新型抗肿瘤药物的潜力。
