翻译后修饰的精氨酰化作为一种全局生物调节因子。
Posttranslational arginylation as a global biological regulator.
机构信息
Department of Animal Biology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
出版信息
Dev Biol. 2011 Oct 1;358(1):1-8. doi: 10.1016/j.ydbio.2011.06.043. Epub 2011 Jul 18.
Abstract
Posttranslational modifications constitute a major field of emerging biological significance as mounting evidence demonstrates their key role in multiple physiological processes. Following in the footsteps of protein phosphorylation studies, new modifications are being shown to regulate protein properties and functions in vivo. Among such modifications, an important role belongs to protein arginylation - posttranslational tRNA-mediated addition of arginine, to proteins by arginyltransferase, ATE1. Recent studies show that arginylation is essential for embryogenesis in many organisms and that it regulates such important processes as heart development, angiogenesis, and tissue morphogenesis in mammals. This review summarizes the key data in the protein arginylation field since its original discovery to date.
摘要
翻译后修饰构成了一个具有重要生物学意义的新兴领域，因为越来越多的证据表明它们在多种生理过程中起着关键作用。继蛋白质磷酸化研究之后，新的修饰被证明在体内调节蛋白质的性质和功能。在这些修饰中，蛋白质精氨酰化起着重要作用——通过精氨酰转移酶ATE1，在翻译后由tRNA介导将精氨酸添加到蛋白质上。最近的研究表明，精氨酰化在许多生物体的胚胎发育中至关重要，并且它调节哺乳动物中的心脏发育、血管生成和组织形态发生等重要过程。本综述总结了自蛋白质精氨酰化最初发现至今该领域的关键数据。
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本文引用的文献
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Protein modification by arginylation.精氨酸化修饰蛋白质
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