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Chemerin: A Novel Link between Inflammation and Atherosclerosis?

作者信息

Rhee Eun-Jung

机构信息

Department of Endocrinology and Metabolism, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.

出版信息

Diabetes Metab J. 2011 Jun;35(3):216-8. doi: 10.4093/dmj.2011.35.3.216. Epub 2011 Jun 30.

DOI:10.4093/dmj.2011.35.3.216
PMID:21785740
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3138091/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5463/3138091/f4aed2e969d2/dmj-35-216-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5463/3138091/f4aed2e969d2/dmj-35-216-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5463/3138091/f4aed2e969d2/dmj-35-216-g001.jpg

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Chemerin: A Novel Link between Inflammation and Atherosclerosis?凯莫瑞蛋白：炎症与动脉粥样硬化之间的新联系？
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2
Chemerin in atherosclerosis.趋化素与动脉粥样硬化。
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Chemerin is associated with markers of inflammation and components of the metabolic syndrome but does not predict coronary atherosclerosis.凯莫瑞蛋白与炎症标志物及代谢综合征的组成成分相关，但不能预测冠状动脉粥样硬化。
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4
Association of chemerin mRNA expression in human epicardial adipose tissue with coronary atherosclerosis.人心外膜脂肪组织中 chemerin mRNA 表达与冠状动脉粥样硬化的关系。
Cardiovasc Diabetol. 2011 Oct 7;10:87. doi: 10.1186/1475-2840-10-87.
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Association of Circulating Chemerin With Subclinical Parameters of Atherosclerosis: Results of a Population-Based Study.循环趋化素与动脉粥样硬化亚临床参数的相关性：一项基于人群的研究结果。
Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1656-1664. doi: 10.1161/ATVBAHA.118.311219. Epub 2018 May 31.
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Chemerin is not associated with subclinical atherosclerosis markers in prediabetes and diabetes.在糖尿病前期和糖尿病患者中，chemerin与亚临床动脉粥样硬化标志物无关。
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Chemerin: A biomarker for cardiovascular disease in diabetic chronic kidney disease patients.凯莫瑞（Chemerin）：糖尿病慢性肾病患者心血管疾病的生物标志物
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Chemerin induces endothelial cell inflammation: activation of nuclear factor-kappa beta and monocyte-endothelial adhesion.凯莫瑞蛋白诱导内皮细胞炎症：核因子-κB的激活及单核细胞与内皮细胞的黏附。
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Circulating concentrations of the novel adipokine chemerin are associated with cardiovascular disease risk in rheumatoid arthritis.循环中新型脂肪因子 chemerin 的浓度与类风湿关节炎患者的心血管疾病风险相关。
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Nutrients. 2022 Dec 11;14(24):5282. doi: 10.3390/nu14245282.
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Chemerin regulates formation and function of brown adipose tissue: Ablation results in increased insulin resistance with high fat challenge and aging.Chemerin 调节棕色脂肪组织的形成和功能：消融会导致高脂肪挑战和衰老时的胰岛素抵抗增加。
FASEB J. 2021 Jul;35(7):e21687. doi: 10.1096/fj.202100156R.
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Chemerin promotes angiogenesis in vivo.凯莫瑞在体内促进血管生成。

本文引用的文献

1
Relationship between Chemerin Levels and Cardiometabolic Parameters and Degree of Coronary Stenosis in Korean Patients with Coronary Artery Disease.韩国冠心病患者趋化素水平与心血管代谢参数及冠状动脉狭窄程度的关系。
Diabetes Metab J. 2011 Jun;35(3):248-54. doi: 10.4093/dmj.2011.35.3.248. Epub 2011 Jun 30.
2
Chemerin, a novel peroxisome proliferator-activated receptor gamma (PPARgamma) target gene that promotes mesenchymal stem cell adipogenesis.Chemerin，一种新型过氧化物酶体增殖物激活受体γ（PPARγ）靶基因，可促进间充质干细胞脂肪生成。
J Biol Chem. 2011 Jul 8;286(27):23982-95. doi: 10.1074/jbc.M111.220491. Epub 2011 May 14.
3
Physiol Rep. 2018 Dec;6(24):e13962. doi: 10.14814/phy2.13962.
4
International Union of Basic and Clinical Pharmacology CIII: Chemerin Receptors CMKLR1 (Chemerin) and GPR1 (Chemerin) Nomenclature, Pharmacology, and Function.国际基础与临床药理学联合会CIII：凯莫瑞受体CMKLR1（凯莫瑞）和GPR1（凯莫瑞）命名、药理学及功能
Pharmacol Rev. 2018 Jan;70(1):174-196. doi: 10.1124/pr.116.013177. Epub 2017 Dec 26.
5
Impact of selective LDL apheresis on serum chemerin levels in patients with hypercholesterolemia.选择性低密度脂蛋白单采术对高胆固醇血症患者血清chemerin水平的影响。
Lipids Health Dis. 2016 Oct 18;15(1):182. doi: 10.1186/s12944-016-0353-x.
6
Evaluation of plasma chemerin levels in patients with non-dipper blood pressure patterns.非杓型血压模式患者血浆chemerin水平的评估。
Med Sci Monit. 2014 Apr 28;20:698-705. doi: 10.12659/MSM.890784.
7
Evaluation of Bovine chemerin (RARRES2) Gene Variation on Beef Cattle Production Traits.牛凯莫瑞蛋白（RARRES2）基因变异对肉牛生产性状的评估
Front Genet. 2012 Mar 29;3:39. doi: 10.3389/fgene.2012.00039. eCollection 2012.
Vascular effects of novel adipocytokines: focus on vascular contractility and inflammatory responses.
新型脂肪细胞因子对血管的影响：重点关注血管收缩性和炎症反应。
Biol Pharm Bull. 2011;34(3):307-10. doi: 10.1248/bpb.34.307.
4
Chemerin: at the crossroads of inflammation and obesity.趋化素：炎症与肥胖的交汇点。
Trends Endocrinol Metab. 2010 Nov;21(11):660-7. doi: 10.1016/j.tem.2010.08.001.
5
Expression of human chemerin induces insulin resistance in the skeletal muscle but does not affect weight, lipid levels, and atherosclerosis in LDL receptor knockout mice on high-fat diet.人趋化素表达在高脂肪饮食的 LDL 受体敲除小鼠中诱导骨骼肌胰岛素抵抗，但不影响体重、血脂水平和动脉粥样硬化。
Diabetes. 2010 Nov;59(11):2898-903. doi: 10.2337/db10-0362. Epub 2010 Aug 19.
6
Adipokines in periaortic and epicardial adipose tissue: differential expression and relation to atherosclerosis.主动脉周围和心外膜脂肪组织中的脂肪细胞因子：差异表达与动脉粥样硬化的关系。
J Atheroscler Thromb. 2010 Feb 26;17(2):115-30. doi: 10.5551/jat.1735. Epub 2010 Feb 10.
7
Identification of chemerin receptor (ChemR23) in human endothelial cells: chemerin-induced endothelial angiogenesis.鉴定人内皮细胞中的趋化素受体（ChemR23）：趋化素诱导的内皮血管生成。
Biochem Biophys Res Commun. 2010 Jan 22;391(4):1762-8. doi: 10.1016/j.bbrc.2009.12.150. Epub 2009 Dec 31.
8
Chemerin is associated with markers of inflammation and components of the metabolic syndrome but does not predict coronary atherosclerosis.凯莫瑞蛋白与炎症标志物及代谢综合征的组成成分相关，但不能预测冠状动脉粥样硬化。
Eur J Endocrinol. 2009 Aug;161(2):339-44. doi: 10.1530/EJE-09-0380. Epub 2009 Jun 4.
9
Chemerin enhances insulin signaling and potentiates insulin-stimulated glucose uptake in 3T3-L1 adipocytes.凯莫瑞蛋白增强3T3-L1脂肪细胞中的胰岛素信号传导并增强胰岛素刺激的葡萄糖摄取。
FEBS Lett. 2008 Mar 5;582(5):573-8. doi: 10.1016/j.febslet.2008.01.023. Epub 2008 Jan 31.
10
Chemerin--a new adipokine that modulates adipogenesis via its own receptor.chemerin——一种通过自身受体调节脂肪生成的新型脂肪因子。
Biochem Biophys Res Commun. 2007 Nov 3;362(4):1013-8. doi: 10.1016/j.bbrc.2007.08.104. Epub 2007 Aug 27.