Harada Takashi
Tokyo Women's Medical University, Japan.
Med Mycol J. 2011;52(2):77-95. doi: 10.3314/jjmm.52.77.
Although onychomycoses are caused by dermatophytes, yeasts or non-dermatophyte molds, tinea unguium describes chronic fungal infections by dermatophytes only. Tinea unguium is a common fungal infection of the nail plate or nail bed with increasing prevalence worldwide. It is not self-limited and shows a higher frequency among the elderly population. In Japan, approximately 10% of the entire population is estimated to have tinea unguium. During the period when only griseofulvin was available for treatment, it was a very difficult disease to treat. Since in the 1990's, however, the introduction of new oral antifungals, itraconazole and terbinafine, initiated a new era in the treatment of tinea unguium. Many excellent textbooks, review articles, and original articles have already been published. This paper considers the circumstances in Japan, epidemiology, causative agents including non-dermatophyte molds, differential diagnosis, diagnostic techniques, the quality of life of the patients with tinea unguium, and then the treatment options are reviewed again.
虽然甲癣是由皮肤癣菌、酵母菌或非皮肤癣菌霉菌引起的,但甲癣仅指由皮肤癣菌引起的慢性真菌感染。甲癣是甲板或甲床常见的真菌感染,在全球范围内患病率呈上升趋势。它不会自行痊愈,在老年人群中发病率更高。在日本,估计约10%的总人口患有甲癣。在只有灰黄霉素可用于治疗的时期,这是一种极难治疗的疾病。然而,自20世纪90年代以来,新型口服抗真菌药伊曲康唑和特比萘芬的引入开启了甲癣治疗的新时代。许多优秀的教科书、综述文章和原创文章已经发表。本文探讨了日本的情况、流行病学、包括非皮肤癣菌霉菌在内的病原体、鉴别诊断、诊断技术、甲癣患者的生活质量,然后再次回顾了治疗选择。