The Ludwig Boltzmann Institute for Retinology and Biomicroscopic Laser Surgery, Vienna, Austria.
Invest Ophthalmol Vis Sci. 2011 Sep 1;52(9):6925-33. doi: 10.1167/iovs.10-6612.
To evaluate the accuracy and reproducibility of retinal thickness measurements in exudative age-related macular degeneration (AMD) by the Spectralis (Heidelberg Engineering, Heidelberg, Germany) and the Cirrus (Carl Zeiss Meditec, Dublin, CA) optical coherence tomography (OCT) systems.
Eyes with exudative age-related macular degeneration were randomly assigned to one of eight groups, each different in the sequence of examiner and OCT system. The 512 × 128 cube program of the Cirrus and the 30° × 25° volume scan containing 32 lines of the Spectralis were performed twice. The correlation between the examinations was expressed by the interclass correlation coefficient (ICC).
Enrolled in the study were 112 patients and 112 eyes (mean age, 76.5 ± 7.9 years; range 51-89), with 14 patients in each group. The mean error scores per line were 0.53 and 0.52 in the Cirrus, significantly (P < 0.001) lower than in the Spectralis (0.83 and 0.98). For automatic central retinal thickness (CRT), the ICC for Cirrus (all examinations calculated) was 0.61 for groups 1 to 4 (the same examiner) and 0.65 for groups 5 to 8 (two different examiners); for Spectralis (13.4% not calculated) the ICC was 0.93 for groups 1 to 4 and 0.86 for groups 5 to 8. After error correction, the Cirrus ICC improved to 1.0 and 0.99 and the Spectralis ICC to 1.0 in both groups.
Considerable differences were found between the two systems, both of which incorporate the spectral-domain technology. Different positioning of segmentation lines, control of localization, density of included scan lines, and number of available maps explain the differences in segmentation quality and reproducibility. Manual correction of segmentation and centralization improves the reproducibility.
评估 Spectralis（德国海德堡工程公司）和 Cirrus（加利福尼亚州都柏林的卡尔蔡司医学技术公司）光学相干断层扫描（OCT）系统测量渗出性年龄相关性黄斑变性（AMD）患者视网膜厚度的准确性和可重复性。
将渗出性年龄相关性黄斑变性患者随机分配到 8 个组中的一个，每个组中检查者和 OCT 系统的顺序不同。Cirrus 的 512×128 立方体程序和 Spectralis 的包含 32 行的 30°×25°容积扫描程序各进行两次。采用组内相关系数（ICC）表示两次检查的相关性。
本研究共纳入 112 例患者（112 只眼），平均年龄 76.5±7.9 岁（范围 51-89 岁），每组 14 例。Cirrus 每条线的平均误差评分分别为 0.53 和 0.52，明显（P<0.001）低于 Spectralis 的 0.83 和 0.98。对于自动中央视网膜厚度（CRT），Cirrus（所有检查计算）的 ICC 为 0.61（同一检查者）和 0.65（两个不同的检查者）；Spectralis（未计算 13.4%）的 ICC 为 0.93（同一检查者）和 0.86（两个不同的检查者）。经过误差校正后，Cirrus 的 ICC 提高到 1.0 和 0.99，Spectralis 的 ICC 提高到 1.0。
这两种都采用光谱域技术的系统之间存在明显差异。不同的分割线定位、定位控制、包含扫描线的密度和可用图谱的数量解释了分割质量和可重复性的差异。手动分割和中心化校正可提高可重复性。
