Division of Public Health Sciences and the Alvin J. Siteman Cancer Center, Department of Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Box 8100, Room 5026, St Louis, MO 63110, USA.
Br J Cancer. 2011 Aug 23;105(5):602-5. doi: 10.1038/bjc.2011.271. Epub 2011 Jul 26.
We investigated prostate involvement during sexually transmitted infections by measuring serum prostate-specific antigen (PSA) as a marker of prostate infection, inflammation, and/or cell damage in young, male US military members.
We measured PSA before and during infection for 299 chlamydia, 112 gonorrhoea, and 59 non-chlamydial, non-gonococcal urethritis (NCNGU) cases, and 256 controls.
Chlamydia and gonorrhoea, but not NCNGU, cases were more likely to have a large rise (40%) in PSA than controls (33.6%, 19.1%, and 8.2% vs 8.8%, P<0.0001, 0.021, and 0.92, respectively).
Chlamydia and gonorrhoea may infect the prostate of some infected men.
我们通过测量血清前列腺特异性抗原 (PSA) 来检测性传播感染期间的前列腺受累情况，PSA 是前列腺感染、炎症和/或细胞损伤的标志物，研究对象为年轻的美国男性军人。
我们对 299 例衣原体、112 例淋病和 59 例非衣原体、非淋病奈瑟菌性尿道炎（NCNGU）病例以及 256 名对照者在感染前后测量了 PSA。
与对照组相比，衣原体和淋病病例发生 PSA 显著升高（≥40%）的可能性更大（33.6%、19.1%和 8.2% vs 8.8%，P<0.0001、0.021 和 0.92），而 NCNGU 病例则不然。
衣原体和淋病可能会感染一些感染男性的前列腺。
