在放线菌素预处理的细胞中对人巨细胞病毒完整复制周期的抑制作用。
Inhibition of a complete replication cycle of human cytomegalovirus in actinomycin pre-treated cells.
作者信息
Landini M P, Musiani M, Zerbini M, Falcieri E, La Placa M
出版信息
J Gen Virol. 1979 Feb;42(2):423-8. doi: 10.1099/0022-1317-42-2-423.
The study of human cytomegalovirus (HCMV) in cultures of human embryo lung fibroblasts, pre-treated with actinomycin D, has shown that under these conditions the virus infection does not proceed beyond the 'early' events of the virus replication cycle. In the same experimental conditions the growth of poliovirus type I, vaccinia virus and herpes simplex type I virus, was completely unaffected. These results suggest that the complete HCMV replication cycle requires some cellular function(s) between early transcription of the input virus genome and virus DNA synthesis.
在用放线菌素D预处理的人胚肺成纤维细胞培养物中对人巨细胞病毒（HCMV）进行的研究表明，在这些条件下，病毒感染不会超过病毒复制周期的“早期”事件。在相同的实验条件下，I型脊髓灰质炎病毒、痘苗病毒和I型单纯疱疹病毒的生长完全不受影响。这些结果表明，完整的HCMV复制周期在输入病毒基因组的早期转录和病毒DNA合成之间需要一些细胞功能。
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