National University of Singapore-Epidemiology and Public Health, Yong Loo Lin School of Medicine, Singapore.
Emerg Infect Dis. 2011 Aug;17(8):1455-62. doi: 10.3201/eid1708.101270.
A total of 828 community-dwelling adults were studied during the course of the pandemic (H1N1) 2009 outbreak in Singapore during June-September 2009. Baseline blood samples were obtained before the outbreak, and 2 additional samples were obtained during follow-up. Seroconversion was defined as a >4-fold increase in antibody titers to pandemic (H1N1) 2009, determined by using hemagglutination inhibition. Men were more likely than women to seroconvert (mean adjusted hazards ratio [HR] 2.23, mean 95% confidence interval [CI] 1.26-3.93); Malays were more likely than Chinese to seroconvert (HR 2.67, 95% CI 1.04-6.91). Travel outside Singapore during the study period was associated with seroconversion (HR 1.76, 95% CI 1.11-2.78) as was use of public transport (HR 1.81, 95% CI 1.05-3.09). High baseline antibody titers were associated with reduced seroconversion. This study suggests possible areas for intervention to reduce transmission during future influenza outbreaks.
在 2009 年 6 月至 9 月新加坡 2009 年 H1N1 流感大流行期间，共有 828 名社区居住的成年人参与了研究。在疫情爆发前采集了基线血液样本，并在随访期间采集了另外 2 个样本。血清转化率定义为对大流行（H1N1）2009 的抗体滴度增加了 4 倍以上，通过血凝抑制试验确定。男性比女性更有可能发生血清转化率（平均调整后的危险比 [HR] 2.23，平均 95%置信区间 [CI] 1.26-3.93）；马来人比中国人更有可能发生血清转化率（HR 2.67，95%CI 1.04-6.91）。在研究期间，新加坡境外旅行（HR 1.76，95%CI 1.11-2.78）和使用公共交通工具（HR 1.81，95%CI 1.05-3.09）与血清转化率相关。基线抗体滴度高与血清转化率降低有关。本研究为未来流感爆发期间减少传播提供了可能的干预领域。
