Department of Clinical Epidemiology, Tan Tock Seng Hospital, Singapore.
Emerg Infect Dis. 2010 Oct;16(10):1554-61. doi: 10.3201/eid1610.100516.
We describe incidence and risk factors for pandemic (H1N1) 2009 virus infection in healthcare personnel during the June-September 2009 epidemic in Singapore. Personnel contributed 3 serologic samples during June-October 2009, with seroconversion defined as a ≥4-fold increase in hemagglutination inhibition titers to pandemic (H1N1) 2009. Of 531 participants, 35 showed evidence of seroconversion. Seroconversion rates were highest in nurses (28/290) and lowest in allied health staff (2/116). Significant risk factors on multivariate analysis were being a nurse (adjusted odds ratio [aOR] 4.5, 95% confidence interval [CI] 1.0-19.6) and working in pandemic (H1N1) 2009 isolation wards (aOR 4.5, 95% CI 1.3-15.6). Contact with pandemic (H1N1) 2009-infected colleagues (aOR 2.5, 95% CI 0.9-6.6) and larger household size (aOR 1.2, 95% CI 1.0-1.4) were of borderline significance. Our study suggests that seroconversion was associated with occupational and nonoccupational risk factors.
我们描述了 2009 年 6 月至 9 月新加坡大流行（H1N1）2009 病毒感染医护人员的发病率和危险因素。人员在 2009 年 6 月至 10 月期间提供了 3 份血清样本，血清学转换定义为对大流行（H1N1）2009 的血凝抑制滴度增加≥4 倍。在 531 名参与者中，有 35 人显示出血清学转换的证据。护士的血清学转换率最高（28/290），辅助卫生人员的血清学转换率最低（2/116）。多变量分析的显著危险因素是护士（调整后的优势比[aOR]4.5，95%置信区间[CI]1.0-19.6）和在大流行（H1N1）2009 隔离病房工作（aOR 4.5，95% CI 1.3-15.6）。与大流行（H1N1）2009 感染同事的接触（aOR 2.5，95% CI 0.9-6.6）和更大的家庭规模（aOR 1.2，95% CI 1.0-1.4）具有边缘显著性。我们的研究表明，血清学转换与职业和非职业危险因素有关。
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