Moses William W
Lawrence Berkeley National Laboratory.
Nucl Instrum Methods Phys Res A. 2011 Aug 21;648 Supplement 1:S236-S240. doi: 10.1016/j.nima.2010.11.092.
The fundamental limits of spatial resolution in positron emission tomography (PET) have been understood for many years. The physical size of the detector element usually plays the dominant role in determining resolution, but the combined contributions from acollinearity, positron range, penetration into the detector ring, and decoding errors in the detector modules often combine to be of similar size. In addition, the sampling geometry and statistical noise further degrade the effective resolution. This paper describes quantitatively describes these effects, discusses potential methods for reducing the magnitude of these effects, and computes the ultimately achievable spatial resolution for clinical and pre-clinical PET cameras.
多年来，人们已经了解正电子发射断层扫描（PET）中空间分辨率的基本限制。探测器元件的物理尺寸通常在决定分辨率方面起主导作用，但共线性、正电子射程、穿透探测器环以及探测器模块中的解码误差等综合影响往往加起来与探测器元件物理尺寸相近。此外，采样几何结构和统计噪声会进一步降低有效分辨率。本文定量描述了这些影响，讨论了降低这些影响程度的潜在方法，并计算了临床和临床前PET相机最终可实现的空间分辨率。
