Kumar P Mahesh, Sasmal D, Mazumder Papiya Mitra
GITAM Institute of Pharmacy, GITAM University, Visakhapatnam, India.
Pharmacognosy Res. 2010 May;2(3):190-4. doi: 10.4103/0974-8490.65520.
Salvia splendens (Labiatae) is widely used in Indian traditional medicine for the control of diabetes mellitus. In this study, the hypoglycemic effects produced by the acute and subacute administration of various extracts of S. splendens were investigated. Both the aqueous extract (SSAE) and the methanolic extract (SSME) from the aerial parts resulted in significant reductions of glycemia in streptozotocin (STZ)-induced diabetic rats after oral administration at a dose of 100 and 200 mg/kg, respectively. On oral administration, aqueous and methanolic extracts showed statistically significant (P < 0.001) effect by reducing the effect of glycemia in STZ-induced diabetic rats. These findings suggest the significant antihyperglycemic potential of the S. splendens extracts in ameliorating the diabetic conditions in diabetic rats. No significant effects were found in the normal rats.
一串红（唇形科）在印度传统医学中被广泛用于控制糖尿病。在本研究中，对一串红各种提取物急性和亚急性给药产生的降血糖作用进行了研究。地上部分的水提取物（SSAE）和甲醇提取物（SSME）分别以100和200mg/kg的剂量口服给药后，均可使链脲佐菌素（STZ）诱导的糖尿病大鼠血糖显著降低。口服后，水提取物和甲醇提取物通过降低STZ诱导的糖尿病大鼠的血糖水平显示出统计学上显著（P<0.001）的效果。这些发现表明，一串红提取物在改善糖尿病大鼠的糖尿病状况方面具有显著的抗高血糖潜力。在正常大鼠中未发现显著影响。
