Department of Ophthalmology, College of Medicine, Hanyang University, Seoul, Korea.
Retina. 2012 Mar;32(3):569-80. doi: 10.1097/IAE.0b013e31821f5d69.
To assess the frequency and severity of segmentation errors in spectral-domain optical coherence tomography, and present an appropriate scan protocol for measuring macular thickness.
In this study we examined 40 eyes of healthy subjects, 45 eyes with retinal pathology and 31 eyes with subretinal pathology. Patients were prospectively imaged using 12 radial scans and 3-dimensional macular cube scans by spectral-domain optical coherence tomography (3D OCT-1000; Topcon Corp., Japan) at the same sitting. Retinal segmentation errors were noted and graded using a subjective, categoric error scale to generate an error score. We compared the macular thickness measurements with and without error correction, and between the two scan protocols.
In this series, 63.8% of eyes (74 of 116 eyes) gave at least 1 segmentation error. Errors were more common in eyes with pathology. There was a significant difference between measurements of macular thickness with and without correcting these errors, regardless of scan protocol (P < 0.05). After error correction of both scan protocols, the macular thickness measurements obtained with the 12 radial scan protocol were equivalent to those obtained with the 3-dimensional macular cube scan protocol.
Segmentation errors were frequent on scans obtained by spectral-domain optical coherence tomography. We recommend the 12 radial scan protocol with error correction as the standard protocol for measuring macular thickness, particularly in clinical studies.
评估谱域光学相干断层扫描中的分段错误频率和严重程度，并提出一种用于测量黄斑厚度的适当扫描方案。
本研究共检查了 40 只健康眼、45 只视网膜病变眼和 31 只视网膜下病变眼。患者前瞻性地使用 12 条径向扫描和 3 维黄斑立方体扫描（3D OCT-1000；日本 Topcon 公司）在同一次就诊中进行成像。使用主观的分类错误量表记录和分级视网膜分段错误，以生成错误评分。我们比较了有和没有错误校正的黄斑厚度测量值，并比较了两种扫描方案之间的差异。
在该系列中，63.8%的眼（116 眼中的 74 眼）出现至少 1 次分段错误。在有病变的眼中，错误更为常见。无论扫描方案如何，有和没有校正这些错误的黄斑厚度测量值之间均存在显著差异（P<0.05）。校正两种扫描方案的错误后，12 条径向扫描方案获得的黄斑厚度测量值与 3 维黄斑立方体扫描方案获得的测量值相当。
谱域光学相干断层扫描获得的扫描中经常出现分段错误。我们建议使用带有错误校正的 12 条径向扫描方案作为测量黄斑厚度的标准方案，特别是在临床研究中。
