Chen Binyao, Chen Haoyu, Zheng Ce, Zhang Mingzhi
Department of Ophthalmology, Joint Shantou International Eye Center, Shantou University and The Chinese University of Hong Kong, Shantou, Guangdong 515041, P.R. China.
Department of Ophthalmology, Shanghai Children's Hospital, Jiaotong University, Shanghai 200062, P.R. China.
Exp Ther Med. 2019 Jun;17(6):4395-4402. doi: 10.3892/etm.2019.7483. Epub 2019 Apr 12.
The aim of the present study was to evaluate the accuracy of the Topcon 3D optical coherence tomography (OCT)-2000 built-in algorithm in analyzing OCT data acquired using the Topcon 3D OCT-1000 instrument. Raw data of 3D macular 512×128 scans acquired using the Topcon 3D OCT-1000 instrument were analyzed using the Topcon 3D OCT-2000. The occurrence and severity of segmentation error (SE) were compared between the built-in algorithms of the two instruments. Agreement in retinal thickness measurement between the two systems was evaluated in normal and abnormal eyes. A total of 87 eyes from 87 patients were included. The image quality score evaluated by Topcon OCT-2000 software was lower than that of OCT-1000. No statistically significant difference was identified in the SE rate (77.01 vs. 74.71%; P=0.864) or mean SE score (15.97 vs. 16.30; P=0.763) of the total scan area between the two algorithms. Intraclass correlation coefficient values for retinal thickness were high (0.951-0.995). The mean paired difference in retinal thickness was 3.72-5.77 µm (P<0.05) in normal and 0.61-9.52 µm (P<0.05) in abnormal eyes. No significant difference in retinal segmentation performance was identified between OCT-2000 and OCT-1000 when analyzing OCT-1000 raw data. In conclusion, retinal thickness measurements analyzed by the two OCT algorithms may be used interchangeably in normal eyes. Abnormal eyes required investigations as big differences in retinal thickness measurements may occur due to severe SEs.
本研究的目的是评估拓普康3D光学相干断层扫描（OCT）-2000内置算法在分析使用拓普康3D OCT-1000仪器采集的OCT数据时的准确性。使用拓普康3D OCT-2000对使用拓普康3D OCT-1000仪器采集的3D黄斑512×128扫描的原始数据进行分析。比较了两种仪器内置算法之间分割误差（SE）的发生率和严重程度。在正常眼和异常眼中评估了两个系统在视网膜厚度测量方面的一致性。共纳入了87例患者的87只眼。拓普康OCT-2000软件评估的图像质量评分低于OCT-1000。两种算法在总扫描区域的SE率（77.01%对74.71%；P=0.864）或平均SE评分（15.97对16.30；P=0.763）方面未发现统计学上的显著差异。视网膜厚度的组内相关系数值较高（0.951 - 0.995）。正常眼中视网膜厚度的平均配对差异为3.72 - 5.77 µm（P<0.05），异常眼中为0.61 - 9.52 µm（P<0.05）。在分析OCT-1000原始数据时，未发现OCT-2000和OCT-1000在视网膜分割性能上有显著差异。总之，两种OCT算法分析的视网膜厚度测量值在正常眼中可互换使用。由于严重的SEs，异常眼需要进行检查，因为视网膜厚度测量可能会出现较大差异。
