在科特迪瓦，血吸虫病和土壤传播性蠕虫感染对在校儿童身体健康的影响。
Effect of schistosomiasis and soil-transmitted helminth infections on physical fitness of school children in Côte d'Ivoire.
机构信息
Department of Epidemiology and Public Health, Swiss Tropical and Public Health Institute, Basel, Switzerland.
出版信息
PLoS Negl Trop Dis. 2011 Jul;5(7):e1239. doi: 10.1371/journal.pntd.0001239. Epub 2011 Jul 19.
BACKGROUND
Schistosomiasis and soil-transmitted helminthiasis are important public health problems in sub-Saharan Africa causing malnutrition, anemia, and retardation of physical and cognitive development. However, the effect of these diseases on physical fitness remains to be determined.
METHODOLOGY
We investigated the relationship between schistosomiasis, soil-transmitted helminthiasis and physical performance of children, controlling for potential confounding of Plasmodium spp. infections and environmental parameters (i.e., ambient air temperature and humidity). A cross-sectional survey was carried out among 156 school children aged 7-15 years from Côte d'Ivoire. Each child had two stool and two urine samples examined for helminth eggs by microscopy. Additionally, children underwent a clinical examination, were tested for Plasmodium spp. infection with a rapid diagnostic test, and performed a maximal multistage 20 m shuttle run test to assess their maximal oxygen uptake (VO(2) max) as a proxy for physical fitness.
PRINCIPAL FINDINGS
The prevalence of Schistosoma haematobium, Plasmodium spp., Schistosoma mansoni, hookworm and Ascaris lumbricoides infections was 85.3%, 71.2%, 53.8%, 13.5% and 1.3%, respectively. Children with single, dual, triple, quadruple and quintuple species infections showed VO(2) max of 52.7, 53.1, 52.2, 52.6 and 55.6 ml kg(-1) min(-1), respectively. The VO(2) max of children with no parasite infections was 53.5 ml kg(-1) min(-1). No statistically significant difference was detected between any groups. Multivariable analysis revealed that VO(2) max was influenced by sex (reference: female, coef. = 4.02, p<0.001) and age (years, coef. = -1.23, p<0.001), but not by helminth infection and intensity, Plasmodium spp. infection, and environmental parameters.
CONCLUSION/SIGNIFICANCE: School-aged children in Côte d'Ivoire showed good physical fitness, irrespective of their helminth infection status. Future studies on children's physical fitness in settings where helminthiasis and malaria co-exist should include pre- and post-intervention evaluations and the measurement of hemoglobin and hematocrit levels and nutritional parameters as potential co-factors to determine whether interventions further improve upon fitness.
背景
在撒哈拉以南非洲，血吸虫病和土壤传播性蠕虫病是重要的公共卫生问题，可导致营养不良、贫血以及身体和认知发育迟缓。然而，这些疾病对身体健康的影响仍有待确定。
方法
我们调查了血吸虫病、土壤传播性蠕虫病与儿童身体机能之间的关系，并控制了疟原虫感染和环境参数（即环境空气温度和湿度）的潜在混杂因素。我们在科特迪瓦的 156 名 7-15 岁在校儿童中开展了一项横断面研究。对每个儿童的两份粪便和两份尿液样本进行镜检，以检查蠕虫卵。此外，儿童还接受了临床检查，用快速诊断测试检测疟原虫感染，并进行最大多阶段 20 米穿梭跑测试，以评估其最大摄氧量（VO2 max）作为身体机能的替代指标。
主要发现
埃及血吸虫、疟原虫、曼氏血吸虫、钩虫和蛔虫感染的流行率分别为 85.3%、71.2%、53.8%、13.5%和 1.3%。单种、两种、三种、四种和五种物种感染的儿童的 VO2 max 分别为 52.7、53.1、52.2、52.6 和 55.6 ml/kg/min。无寄生虫感染的儿童的 VO2 max 为 53.5 ml/kg/min。各组之间无统计学差异。多变量分析显示，VO2 max 受性别（参考：女性，系数=4.02，p<0.001）和年龄（岁，系数=-1.23，p<0.001）影响，但不受蠕虫感染和强度、疟原虫感染以及环境参数影响。
结论/意义：科特迪瓦的学龄儿童身体健康状况良好，不论其是否感染蠕虫。在寄生虫病和疟疾共存的环境中开展儿童身体健康状况的研究时，应包括干预前后的评估以及血红蛋白和血细胞比容水平和营养参数的测量，以确定干预措施是否能进一步提高健康水平。
Zotero 插件