UCL Institute of Cognitive Neuroscience, 17 Queen Square, London WC1N 3AR, UK; UCL Institute of Neurology, Queen Square, London WC1N 3BG, UK.
Curr Opin Neurobiol. 2011 Oct;21(5):734-44. doi: 10.1016/j.conb.2011.07.002. Epub 2011 Aug 4.
Neuronal firing in the hippocampal formation (HF) of freely moving rodents shows striking examples of spatialorganization in the form of place, directional, boundary vector and grid cells. The firing of place and grid cells shows an intriguing form of temporal organization known as 'theta phase precession'. We review the mechanisms underlying theta phase precession of place cell firing, ranging from membrane potential oscillations to recurrent connectivity, and the relevant intra-cellular and extra-cellular data. We then consider the use of these models to explain the spatial structure of grid cell firing, and review the relevant intra-cellular and extra-cellular data. Finally, we consider the likely interaction between place cells, grid cells and boundary vector cells in estimating self-location as a compromise between path-integration and environmental information.
自由活动的啮齿动物的海马结构（HF）中的神经元放电显示了空间组织的惊人示例，其形式为位置、方向、边界向量和网格细胞。位置和网格细胞的放电显示出一种有趣的时间组织形式，称为“theta 相位进动”。我们回顾了位置细胞放电的 theta 相位进动的基础机制，从膜电位振荡到递归连接，以及相关的细胞内和细胞外数据。然后，我们考虑使用这些模型来解释网格细胞放电的空间结构，并回顾相关的细胞内和细胞外数据。最后，我们考虑位置细胞、网格细胞和边界向量细胞在估计自身位置时可能的相互作用，这是路径积分和环境信息之间的一种折衷。
